help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on March 24, 2004, doi:10.1164/rccm.200401-123OC

Am. J. Respir. Crit. Care Med., Volume 169, Number 10, May 2004, 1125-1130

A more recent version of this article appeared on May 15, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200401-123OCv1
169/10/1125    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kanazawa, H.
Right arrow Articles by Yoshikawa, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kanazawa, H.
Right arrow Articles by Yoshikawa, J.

Submitted on February 4, 2004
Accepted on March 19, 2004

Role of Microvascular Permeability on Physiologic Differences in Asthma and Eosinophilic Bronchitis

Hiroshi Kanazawa1*, Saeko Nomura1, and Junichi Yoshikawa1

1 Department of Respiratory Medicine, Osaka City University, Osaka, Japan

* To whom correspondence should be addressed. E-mail: kanazawa-h{at}med.osaka-cu.ac.jp.

Asthma and eosinophilic bronchitis are characterized by similar type of eosinophilic inflammation. However, eosinophilic bronchitis differs from asthma in that there is no variable airflow obstruction or airway hyperresponsiveness. We evaluated the roles of vascular endothelial growth factor (VEGF) and microvascular permeability in causing these differences between the two diseases. Inflammatory indexes in induced sputum, exhaled nitric oxide (NO) levels, and vascular permeability index were examined in 11 normal controls, 19 beclomethasone dipropionate (BDP)-treated asthmatics, 20 BDP-nontreated asthmatics, and 17 patients with eosinophilic bronchitis. The percentage of eosinophils in sputum and exhaled NO levels were significantly higher in BDP-nontreated asthmatics and patients with eosinophilic bronchitis than in other two groups. However, VEGF levels and vascular permeability index were significantly higher in BDP-nontreated (VEGF: 4710 (1150) pg/mL, p<0.0001; vascular permeability index: 0.028 (0.009), p<0.0001) and -treated (2560 (1070) pg/mL, p=0.0002; 0.016 (0.006), p=0.004) asthmatics than in patients with eosinophilic bronchitis (1120 (800) pg/mL; 0.01 (0.005)) and normal controls (1390 (1280) pg/mL; 0.008 (0.003)). We found significant correlations between VEGF level and airway vascular permeability index in all patient groups. Thus, interaction between airway microcirculation and VEGF may be a key element in differences in airway function between asthma and eosinophilic bronchitis.
Key words: airway hyperresponsiveness, microvascular leakage, sputum eosinophilia, vascular endothelial growth factor, variable airflow obstruction




This article has been cited by other articles:


Home page
 ThoraxHome page
P Paredi and P J Barnes
The airway vasculature: recent advances and clinical implications
Thorax, May 1, 2009; 64(5): 444 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. S. Lee, S. J. Park, S. R. Kim, K. H. Min, K. Y. Lee, Y. H. Choe, S. H. Hong, Y. R. Lee, J. S. Kim, S. J. Hong, et al.
Inhibition of VEGF blocks TGF-{beta}1 production through a PI3K/Akt signalling pathway
Eur. Respir. J., March 1, 2008; 31(3): 523 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Siddiqui, F. Hollins, S. Saha, and C. E. Brightling
Inflammatory cell microlocalisation and airway dysfunction: cause and effect?
Eur. Respir. J., December 1, 2007; 30(6): 1043 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
H. Kanazawa and T. Yoshikawa
Up-Regulation of Thrombin Activity Induced by Vascular Endothelial Growth Factor in Asthmatic Airways
Chest, October 1, 2007; 132(4): 1169 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
H. Kanazawa, S. Nomura, and K. Asai
Roles of Angiopoietin-1 and Angiopoietin-2 on Airway Microvascular Permeability in Asthmatic Patients
Chest, April 1, 2007; 131(4): 1035 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Tigani, C. Cannet, H. Karmouty-Quintana, F.-X. Ble, S. Zurbruegg, E. Schaeublin, J. R. Fozard, and N. Beckmann
Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L644 - L653.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. V. Avdalovic, L. F. Putney, E. S. Schelegle, L. Miller, J. L. Usachenko, N. K. Tyler, C. G. Plopper, L. J. Gershwin, and D. M. Hyde
Vascular Remodeling Is Airway Generation-Specific in a Primate Model of Chronic Asthma
Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1069 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. S. Lee, K. H. Min, S. R. Kim, S. J. Park, H. S. Park, G. Y. Jin, and Y. C. Lee
Vascular Endothelial Growth Factor Modulates Matrix Metalloproteinase-9 Expression in Asthma
Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 161 - 170.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Siddiqui, C E Brightling, A-S Jang, S-W Park, and C-S Park
Differences in airway wall remodelling in asthma and EB.
Thorax, June 1, 2006; 61(6): 547 - 547.
[Full Text] [PDF]

Home page
 ChestHome page
A. M. O. Abdel-Rahman, S. A. F. El-Sahrigy, and S. I. Bakr
A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack.
Chest, February 1, 2006; 129(2): 266 - 271.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Horvath and A. Wanner
Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma
Eur. Respir. J., January 1, 2006; 27(1): 172 - 187.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S-W Park, J-S Park, Y-M Lee, J-H Lee, A-S Jang, D-J Kim, Y Hwangbo, S-T Uh, Y-H Kim, and C-S Park
Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness
Thorax, January 1, 2006; 61(1): 41 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. E. Mapp, P. Boschetto, P. Maestrelli, and L. M. Fabbri
Occupational Asthma
Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 280 - 305.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Fabbri, S. P. Peters, I. Pavord, S. E. Wenzel, S. C. Lazarus, W. MacNee, F. Lemaire, and E. Abraham
Allergic Rhinitis, Asthma, Airway Biology, and Chronic Obstructive Pulmonary Disease in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 686 - 698.
[Full Text] [PDF]

Home page
 ChestHome page
H. Kanazawa
Effects of Pranlukast on Vascular Endothelial Growth Factor Levels in Asthma
Chest, April 1, 2005; 127(4): 1461 - 1461.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. C. Thomson and R. Chaudhuri
Why Is Eosinophilic Bronchitis not Asthma?
Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 4 - 5.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  New Orleans Int'l Conf