help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on June 7, 2004, doi:10.1164/rccm.200312-1726CR

Am. J. Respir. Crit. Care Med., Volume 170, Number 7, October 2004, 811-814

A more recent version of this article appeared on October 1, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200312-1726CRv1
170/7/811    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mal, H.
Right arrow Articles by Fournier, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mal, H.
Right arrow Articles by Fournier, M.

Submitted on December 17, 2003
Accepted on June 7, 2004

Recurrence of Pulmonary Emphysema in an {alpha}-1 Proteinase Inhibitor-deficient Lung Transplant Recipient

Herve Mal1*, Christophe Guignabert2, Gabriel Thabut1, Marie Pia d'Ortho2, Olivier Brugiere1, Gaelle Dauriat1, Rolana Marrash-Chahla1, Anne-Sophie Rangheard1, Guy Leseche1, and Michel Fournier1

1 Service de Pneumologie et Reanimation Respiratoire, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France, 2 Unite INSERM 492 et Service de Physiologie, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France

* To whom correspondence should be addressed. E-mail: herve.mal{at}bjn.ap-hop-paris.fr.

Several type of primary disease may recur after lung transplantation but recurrence of pulmonary emphysema has so far never been published. We report the case of a 49 year-old caucasian male who underwent single lung transplantation for emphysema related to {alpha}1-antitrypsin deficiency and to superimposed smoking. The postoperative course was complicated by several rejection episodes. Subsequently the patient remained stable without evidence of graft dysfunction for more than ten years but he resumed a light smoking after 8 years posttransplant. Eleven years after transplant, while the patient was still asymptomatic and had a stable lung function, recurrence of emphysema on the grafted side was diagnosed on computerized tomography of the thorax. One year later, the patient began to experience a moderate decline in lung function. Two separate bronchoalveolar lavage performed after the onset of the recurrence disclosed a significant elastolytic activity related to neutrophil serine-elastase in lavage fluid. In summary, we describe a case of recurrence of pulmonary emphysema in a patient with {alpha}1-antitrypsin deficiency. The resumption of smoking has probably played a central role in the presence of elastolytic activity in lavage fluid and in the recurrence of emphysema.
Key words: emphysema, pathophysiology, lung transplantation, COPD




This article has been cited by other articles:


Home page
 Ther Adv Respir DisHome page
D. A. Ngan, S. V. Vickerman, D. J. Granville, S. F. P. Man, and D. D. Sin
The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease
Therapeutic Advances in Respiratory Disease, June 1, 2009; 3(3): 113 - 129.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Fabbri, S. P. Peters, I. Pavord, S. E. Wenzel, S. C. Lazarus, W. MacNee, F. Lemaire, and E. Abraham
Allergic Rhinitis, Asthma, Airway Biology, and Chronic Obstructive Pulmonary Disease in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 686 - 698.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  CCM abstracts