help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on June 1, 2004, doi:10.1164/rccm.200311-1583OC

Am. J. Respir. Crit. Care Med., Volume 170, Number 5, September 2004, 534-540

A more recent version of this article appeared on September 1, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200311-1583OCv1
170/5/534    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lucas, J. S
Right arrow Articles by Clough, J. B
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lucas, J. S
Right arrow Articles by Clough, J. B

Submitted on November 20, 2003
Accepted on May 31, 2004

Small Size at Birth and Greater Postnatal Weight Gain: Relations to Diminished Infant Lung Function

Jane S Lucas1, Hazel M Inskip2, Keith M Godfrey2*, Claire T Foreman1, John O Warner1, Rachael K Gregson1, and Joanne B Clough1

1 Allergy and Inflammation Sciences Division, University of Southampton, Southampton General Hospital, Southampton, Hants, United Kingdom, 2 MRC Environmental Epidemiology Unit, University of Southampton, Southampton, Hants, United Kingdom

* To whom correspondence should be addressed. E-mail: kmg{at}mrc.soton.ac.uk.

Recent evidence suggests that impaired lung development is linked with diminished lung function and an increased risk of chronic obstructive airways disease in adulthood. To examine environmental influences on early lung development, we measured lung function in 131 normal term infants aged 5-14 weeks. Adjusting for age at measurement, forced expiratory volume at 0.4 sec fell by 4.4% for each standard deviation decrease in birthweight (P=0.047); when adjusted for forced vital capacity, forced expiratory volume at 0.4 sec was not related to birthweight but fell by 3.2% per standard deviation increase in infant weight gain (P=0.001). Age and gender-adjusted total respiratory system compliance fell by 7.0% per standard deviation decrease in birthweight (P<0.001) but was not related to infant weight gain. In univariate analyses, age-adjusted forced expiratory flow at functional residual capacity was not related to birthweight, but decreased by 11.0% per standard deviation increase in infant weight gain (P=0.007). Respiratory rate rose by 5.1% per standard deviation increase in infant weight gain (P=0.001). Lung function measurements were not related to infant feeding. The observations suggest that lower rates of fetal growth and higher rates of early infancy weight gain are associated with impaired lung development.
Key words: weight gain, lung function, infant, forced expiratory flow rates, forced expiratory volume.




This article has been cited by other articles:


Home page
 ThoraxHome page
S Turner, G Zhang, S Young, M Cox, J Goldblatt, L Landau, and P Le Souef
Associations between postnatal weight gain, change in postnatal pulmonary function, formula feeding and early asthma
Thorax, March 1, 2008; 63(3): 234 - 239.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D. Canoy, J. Pekkanen, P. Elliott, A. Pouta, J. Laitinen, A.-L. Hartikainen, P. Zitting, S. Patel, M. P Little, and M.-R. Jarvelin
Early growth and adult respiratory function in men and women followed from the fetal period to adulthood
Thorax, May 1, 2007; 62(5): 396 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
Respiratory
Arch. Dis. Child., April 1, 2007; 92(suppl_1): A16 - A19.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Friedrich, R. T. Stein, P. M. C. Pitrez, A. L. Corso, and M. H. Jones
Reduced Lung Function in Healthy Preterm Infants in the First Months of Life
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 442 - 447.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
H. M Inskip, K. M Godfrey, S. M Robinson, C. M Law, D. J. Barker, C. Cooper, and and the SWS Study Group
Cohort profile: The Southampton Women's Survey
Int. J. Epidemiol., February 1, 2006; 35(1): 42 - 48.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
G. Tino
Clinical Year in Review III: Sleep-disordered Breathing, Interstitial Lung Disease, Lung Transplantation, and Pediatric Pulmonary Disease
Proceedings of the ATS, November 1, 2005; 2(4): 251 - 254.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush, F. Accurso, W. MacNee, S. C. Lazarus, and E. Abraham
Cystic Fibrosis, Pediatrics, Control of Breathing, Pulmonary Physiology and Anatomy, and Surfactant Biology in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 545 - 553.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS State of the Art Course 2008