Published ahead of print on June 23, 2004, doi:10.1164/rccm.200311-1539WS
Am. J. Respir. Crit. Care Med., Volume 170, Number 6, September 2004, 683-690
A more recent version of this article appeared on September 15, 2004
Submitted on December 12, 2003
Accepted on June 16, 2004
Future Research Directions in Asthma: An NHLBI Working Group Report
William Busse1, Susan Banks-Schlegel2*, Patricia Noel2, Hector Ortega2, Virginia Taggart2, and Jack Elias3
1 Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, USA,
2 Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, MD, USA,
3 Department of Internal Medicine, Yale University, New Haven, CT, USA
* To whom correspondence should be addressed. E-mail: Schleges{at}nih.gov.
Over the last 20 years, the prevalence of asthma has nearly doubled and now affects 8-10% of the population in the United States. Asthma also remains a major illness in terms of morbidity and suffering and is the leading cause of hospitalizations in children under 15 years of age. Because asthma poses a life-long burden to patients and society, efforts to increase the understanding of its pathogenesis is a key factor leading to its control and cure. Consequently, the National Heart, Lung, and Blood Institute (NHLBI) convened a Working Group of extramural experts, entitled "Future Research Directions in Asthma," on April 9-10, 2003, to identify research areas of greatest promise and opportunity in the field of asthma. The priority areas identified for research in asthma include: (1) innate immunity, adaptive immunity, and tolerance; (2) mechanisms and consequences of persistent asthma and asthma exacerbations; (3) airway remodeling: clinical consequences and reversibility (clinical relevance and resolution); (4) genetics/gene-environment interactions, pharmacogenetics; (5) intervention/ prevention/therapeutics; and (6) vascular basis of asthma.
Key words: asthma, airway lung disease
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Copyright © 2004 American Thoracic Society
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