Published ahead of print on March 4, 2004, doi:10.1164/rccm.200310-1473OC Am. J. Respir. Crit. Care Med., Volume 169, Number 9, May 2004, 1019-1021 A more recent version of this article appeared on May 1, 2004
Submitted on October 29, 2003 Effect of Caffeine Ingestion on Exhaled Nitric Oxide Measurements in Patients with AsthmaElizabeth S Taylor1,1 Otago Respiratory Reseach Unit, Dunedin School of Medicine, University of Otago Medical School, Dunedin, New Zealand * To whom correspondence should be addressed. E-mail: robin.taylor{at}stonebow.otago.ac.nz.
Exhaled nitric oxide (FENO) measurements may be influenced by a number of confounding factors. Recent reports have offered conflicting evidence as to whether caffeine consumption increases or decreases FENO. In this study we aimed to confirm whether caffeine ingestion affects FENO in patients with asthma. On two separate days, 20 asthmatic patients (10 steroid-naive and 10 steroid-treated) received a standard cup of either caffeinated or non-caffeinated coffee (15g) (control) in a randomized, double-blind, cross-over manner. FENO measurements were obtained at baseline, and at 30, 60, 120 and 180 minutes after ingestion. Serum caffeine levels were also measured at 0 and 60 minutes. No significant changes in FENO occurred following caffeine compared to the control. We conclude that caffeinated foods and beverages are unlikely to influence FENO in asthmatic subjects acutely, and protocols for laboratory measurement do not require to take this factor into account. Key words: exhaled nitric oxide, measurement, caffeine, asthma
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