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Published ahead of print on May 13, 2004, doi:10.1164/rccm.200308-1073WS

Am. J. Respir. Crit. Care Med., Volume 170, Number 5, September 2004, 567-571

A more recent version of this article appeared on September 1, 2004
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Submitted on August 1, 2003
Accepted on May 10, 2004

NHLBI Working Group: Future Directions in Sarcoidosis Research

William J Martin II1, Michael C Iannuzzi2, Dorothy B Gail3, and Hannah H Peavy3*

1 Office of the Dean, University of Cincinnati, College of Medicine, Cincinnati, OH, USA, 2 Pulmonary and Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY, USA, 3 Division of Lung Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

* To whom correspondence should be addressed. E-mail: peavyh{at}nhlbi.nih.gov.

Sarcoidosis is a systemic granulomatous disease of unknown etiology that primarily affects the lungs. The etiology remains unclear; however, environmental, genetic, ethnic and familial factors probably modify expression of the disease. As an example, African-Americans are at greater risk of mortality and morbidity than Caucasians, and more often have a family history of sarcoidosis. Most patients with sarcoidosis recover spontaneously, but some develop chronic, debilitating disease. Corticosteroids and other drugs, while effective at controlling disease activity, may not influence the overall course of disease. Because of the many uncertainties about the pathogenesis, course, and management of sarcoidosis, the National Heart, Lung, and Blood Institute convened a working group to identify future research directions and opportunities for sarcoidosis. These include developing a tissue bank, using novel methods to identify genetic factors, studying the immunopathogenesis using human tissue and animal models, exploring new approaches to diagnose and manage disease, and finally, conducting randomized controlled trials to assess new therapies.
Key words: Lung disease, Genetics, Granuloma, Environmental, National Institutes of Health (United States)




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