help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on December 11, 2003, doi:10.1164/rccm.200307-1018OC

Am. J. Respir. Crit. Care Med., Volume 169, Number 4, February 2004, 468-472

A more recent version of this article appeared on February 15, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200307-1018OCv1
169/4/468    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hachem, R. R
Right arrow Articles by Trulock, E. P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hachem, R. R
Right arrow Articles by Trulock, E. P

Submitted on July 31, 2003
Accepted on December 5, 2003

The Predictive Value of Bronchiolitis Obliterans Syndrome Stage 0-p

Ramsey R Hachem1*, Murali M Chakinala1, Roger D Yusen1, John P Lynch1, Aviva A Aloush2, G. Alexander Patterson2, and Elbert P Trulock1

1 Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA, 2 Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO, USA

* To whom correspondence should be addressed. E-mail: rhachem{at}im.wustl.edu.

Bronchiolitis obliterans syndrome remains the main cause of graft loss after lung transplantation. Stage 0-p was recently added to the staging criteria to detect early deterioration in allograft function that might presage bronchiolitis obliterans syndrome stage 1. We assessed the predictive value of stage 0-p by retrospectively analyzing spirometric data for 203 adult bilateral lung transplant recipients. The FEV1 criterion for stage 0-p had a positive predictive value of 79% and a negative predictive value of 82%. In contrast, the FEF25-75 criterion for stage 0-p had a positive predictive value of 52% and a negative predictive value of 72%. Fifty-seven percent of subjects who developed stage 0-p by the FEV1 criterion progressed to stage 1 within one year, while only 37% of those who developed stage 0-p by the FEF25-75 criterion progressed to stage 1 within one year. We conclude that the FEV1 criterion for stage 0-p is a reasonable predictor of bronchiolitis obliterans syndrome stage 1 after bilateral lung transplantation, but the FEF25-75 criterion for stage 0-p is not predictive of bronchiolitis obliterans syndrome stage 1 after bilateral lung transplantation.
Key words: Lung transplantation, chronic rejection, diagnosis, spirometry




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
J. A. Belperio, S. S. Weigt, M. C. Fishbein, and J. P. Lynch III
Chronic Lung Allograft Rejection: Mechanisms and Therapy
Proceedings of the ATS, January 15, 2009; 6(1): 108 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Vos, B. M. Vanaudenaerde, N. Geudens, L. J. Dupont, D. E. Van Raemdonck, and G. M. Verleden
Pseudomonal airway colonisation: risk factor for bronchiolitis obliterans syndrome after lung transplantation?
Eur. Respir. J., May 1, 2008; 31(5): 1037 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J.-F. Cordier
Challenges in pulmonary fibrosis {middle dot} 2 : Bronchiolocentric fibrosis
Thorax, July 1, 2007; 62(7): 638 - 649.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Van Muylem, C. Knoop, and M. Estenne
Early Detection of Chronic Pulmonary Allograft Dysfunction by Exhaled Biomarkers
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 731 - 736.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P A de Jong, J D Dodd, H O Coxson, C Storness-Bliss, P D Pare, J R Mayo, and R D Levy
Bronchiolitis obliterans following lung transplantation: early detection using computed tomographic scanning
Thorax, September 1, 2006; 61(9): 799 - 804.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
V. N. Lama, S. Murray, J. A. Mumford, K. R. Flaherty, A. Chang, G. B. Toews, M. Peters-Golden, and F. J. Martinez
Prognostic Value of Bronchiolitis Obliterans Syndrome Stage 0-p in Single-Lung Transplant Recipients
Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 379 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. Higenbottam
Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease: A Case for Treatment
Proceedings of the ATS, April 1, 2005; 2(1): 12 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. D. Bradley, Y. E. Miller, F. J. Martinez, D. C. Angus, W. MacNee, and E. Abraham
Interstitial Lung Disease, Lung Cancer, Lung Transplantation, Pulmonary Vascular Disorders, and Sleep-disordered Breathing in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 675 - 685.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. P. Khalifah, R. R. Hachem, M. M. Chakinala, K. B. Schechtman, G. A. Patterson, D. P. Schuster, T. Mohanakumar, E. P. Trulock, and M. J. Walter
Respiratory Viral Infections Are a Distinct Risk for Bronchiolitis Obliterans Syndrome and Death
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 181 - 187.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  ATS State of the Art 2009