help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on September 4, 2003, doi:10.1164/rccm.200306-877OC

Am. J. Respir. Crit. Care Med., Volume 168, Number 11, December 2003, 1312-1316

A more recent version of this article appeared on December 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200306-877OCv1
168/11/1312    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lind, D. L
Right arrow Articles by Burchard, E. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lind, D. L
Right arrow Articles by Burchard, E. G

Submitted on July 4, 2003
Accepted on September 1, 2003

ADAM33 is Not Associated with Asthma in Puerto Rican or Mexican Populations

Denise L Lind1, Shweta Choudhry2, Ngim Ung2, Elad Ziv1, Pedro C Avila1, Keyan Salari2, Natasha E Coyle2, Sylvette Nazario3, Jose R Rodriguez-Santana4, Jorge Salas5, Moises Selman5, Homer A Boushey1, Scott T Weiss6, Rocio Chapela5, Jean G Ford7, William Rodriguez-Cintron3, Edwin K Silverman6, Dean Sheppard2, Pui-Yan Kwok1, and Esteban G Burchard2*

1 University of California, San Francisco, San Francisco, CA, USA, 2 University of California, San Francisco, San Francisco, CA, USA; Medicine, San Francisco General Hospital, Lung Biology Center, San Francisco, CA, USA, 3 Medicine, San Juan VAMC, Unversity of Puerto Rico School of Medicine, San Juan, PR, USA, 4 Pediatric Pulmonology, Pediatric Pulmonary Program of San Juan, Cardiovascular Center of Puerto Rico, San Juan, PR, USA, 5 Medicine, Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, MX, Mexico, 6 Medicine, Brigham and Women's Hospital, Boston, MA, USA, 7 Medicine, The Harlem Lung Center, Harlem Hospital and Columbia University, New York, NY, USA; Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: eburch{at}itsa.ucsf.edu.

A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. We have genotyped 6 SNPs used in that study in Puerto Rican and Mexican populations from the Genetics of Asthma in Latino Americans (GALA) study. We chose to study these two populations because in the U.S., Puerto Ricans have the highest asthma prevalence, morbidity and mortality, and Mexicans have the lowest. We used the Transmission Disequilibrium Test (TDT) to analyze associations between the ADAM33 gene variants with asthma, asthma severity, bronchodilator responsiveness and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (asthmatic proband and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the TDT or case-control results showed significant associations in either of the populations. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or asthma-associated phenotypes in Mexicans or Puerto Ricans.
Key words: genetics, asthma, Latino populations, ADAM33




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Galanter, S. Choudhry, C. Eng, S. Nazario, J. R. Rodriguez-Santana, J. Casal, A. Torres-Palacios, J. Salas, R. Chapela, H. G. Watson, et al.
ORMDL3 Gene Is Associated with Asthma in Three Ethnically Diverse Populations
Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1194 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. P. Hersh, B. A. Raby, M. E. Soto-Quiros, A. J. Murphy, L. Avila, J. Lasky-Su, J. S. Sylvia, B. J. Klanderman, C. Lange, S. T. Weiss, et al.
Comprehensive Testing of Positionally Cloned Asthma Genes in Two Populations
Am. J. Respir. Crit. Care Med., November 1, 2007; 176(9): 849 - 857.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. V. Scirica and J. C. Celedon
Genetics of Asthma: Potential Implications for Reducing Asthma Disparities
Chest, November 1, 2007; 132(5_suppl): 770S - 781S.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
F. Sampsonas, A. Kaparianos, D. Lykouras, K. Karkoulias, and K. Spiropoulos
DNA sequence variations of metalloproteinases: their role in asthma and COPD
Postgrad. Med. J., April 1, 2007; 83(978): 244 - 250.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M. M E Gosman, H Marike Boezen, C. C van Diemen, J. B Snoeck-Stroband, T. S Lapperre, P. S Hiemstra, N. H T ten Hacken, J. Stolk, D. S Postma, and the GLUCOLD Study Group
A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology
Thorax, March 1, 2007; 62(3): 242 - 247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Choudhry, E. G. Burchard, L. N. Borrell, H. Tang, I. Gomez, M. Naqvi, S. Nazario, A. Torres, J. Casal, J. C. Martinez-Cruzado, et al.
Ancestry-Environment Interactions and Asthma Risk among Puerto Ricans
Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1088 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Chen, X. Huang, and D. Sheppard
ADAM33 Is Not Essential for Growth and Development and Does Not Modulate Allergic Asthma in Mice.
Mol. Cell. Biol., September 1, 2006; 26(18): 6950 - 6956.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. T. Holgate, Y. Yang, H.-M. Haitchi, R. M. Powell, J. W. Holloway, H. Yoshisue, Y. Y. Pang, J. Cakebread, and D. E. Davies
The Genetics of Asthma: ADAM33 as an Example of a Susceptibility Gene.
Proceedings of the ATS, July 1, 2006; 3(5): 440 - 443.
[Abstract] [Full Text] [PDF]

Home page
 AJPHHome page
D. Rose, D. M. Mannino, and B. P. Leaderer
Asthma Prevalence Among US Adults, 1998-2000: Role of Puerto Rican Ethnicity and Behavioral and Geographic Factors
Am J Public Health, May 1, 2006; 96(5): 880 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-Y. Lee, S.-W. Park, H. K. Chang, H. Y. Kim, T. Rhim, J.-H. Lee, A.-S. Jang, E.-S. Koh, and C.-S. Park
A Disintegrin and Metalloproteinase 33 Protein in Patients with Asthma: Relevance to Airflow Limitation
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 729 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. Hunninghake, S. T. Weiss, and J. C. Celedon
Asthma in Hispanics
Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 143 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
J. Kere
Mapping and identifying genes for asthma and psoriasis
Phil Trans R Soc B, August 29, 2005; 360(1460): 1551 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. C. van Diemen, D. S. Postma, J. M. Vonk, M. Bruinenberg, J. P. Schouten, and H. M. Boezen
A Disintegrin and Metalloprotease 33 Polymorphisms and Lung Function Decline in the General Population
Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 329 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Simpson, N. Maniatis, F. Jury, J. A. Cakebread, L. A. Lowe, S. T. Holgate, A. Woodcock, W. E. R. Ollier, A. Collins, A. Custovic, et al.
Polymorphisms in A Disintegrin and Metalloprotease 33 (ADAM33) Predict Impaired Early-Life Lung Function
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 55 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. M. Haitchi, R. M. Powell, T. J. Shaw, P. H. Howarth, S. J. Wilson, D. I. Wilson, S. T. Holgate, and D. E. Davies
ADAM33 Expression in Asthmatic Airways and Human Embryonic Lungs
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 958 - 965.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S T Holgate and J W Holloway
Is big beautiful? The continuing story of ADAM33 and asthma
Thorax, April 1, 2005; 60(4): 263 - 264.
[Full Text] [PDF]

Home page
 ThoraxHome page
J Blakey, E Halapi, U S Bjornsdottir, A Wheatley, S Kristinsson, R Upmanyu, K Stefansson, H Hakonarson, and I P Hall
Contribution of ADAM33 polymorphisms to the population risk of asthma
Thorax, April 1, 2005; 60(4): 274 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
K. G. Ackerman, H. Huang, H. Grasemann, C. Puma, J. B. Singer, A. E. Hill, E. Lander, J. H. Nadeau, G. A. Churchill, J. M. Drazen, et al.
Interacting genetic loci cause airway hyperresponsiveness
Physiol Genomics, March 21, 2005; 21(1): 105 - 111.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Lazarus, B. A. Raby, C. Lange, E. K. Silverman, D. J. Kwiatkowski, D. Vercelli, W. J. Klimecki, F. D. Martinez, and S. T. Weiss
TOLL-like Receptor 10 Genetic Variation Is Associated with Asthma in Two Independent Samples
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 594 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. E. King, N. Zimmermann, S. M. Pope, P. C. Fulkerson, N. M. Nikolaidis, A. Mishra, D. P. Witte, and M. E. Rothenberg
Expression and Regulation of a Disintegrin and Metalloproteinase (ADAM) 8 in Experimental Asthma
Am. J. Respir. Cell Mol. Biol., September 1, 2004; 31(3): 257 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. A. Raby and S. T. Weiss
ADAM33: Where Are We Now?
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 1 - 2.
[Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. T. Weiss and B. A. Raby
Asthma genetics 2003
Hum. Mol. Genet., April 1, 2004; 13(90001): R83 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 265 - 276.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  ATS 2008 State of the Art Course