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Published ahead of print on November 3, 2003, doi:10.1164/rccm.200306-800OC

Am. J. Respir. Crit. Care Med., Volume 169, Number 2, January 2004, 209-213

A more recent version of this article appeared on January 15, 2004
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Submitted on June 17, 2003
Accepted on October 27, 2003

Interrupter resistance and wheezing phenotypes at 4 years of age

Jessica E Brussee1, Henriette A Smit1*, Laurens P Koopman2, Alet H Wijga3, Marjan Kerkhof4, Karen Corver2, Ada P H Vos5, Jorrit Gerritsen6, Diederick E Grobbee7, Bert Brunekreef5, Peter JF M Merkus2, and Johan C de Jongste2

1 Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands, 2 Department of Paediatrics, Division of Respiratory Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, 3 Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands, 4 Department of Epidemiology and Statistics, University of Groningen, Groningen, The Netherlands, 5 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands, 6 Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen, The Netherlands, 7 Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands

* To whom correspondence should be addressed. E-mail: jet.smit{at}rivm.nl.

It is difficult to distinguish young children with respiratory symptoms who will develop asthma from those with transient symptoms only. Measurement of interrupter resistance may help to identify children at high risk of asthma. The aim of this study is to compare interrupter resistance in 4-year-old children with different wheezing phenotypes. All children participated in the Prevention and Incidence of Asthma and Mite Allergy cohort, a prospective birth cohort of over 4000 children. At 4 years of age, data on interrupter resistance plus wheezing phenotype were available for 838 children. Mean interrupter resistance values (95% confidence interval) were 0.95 (0.93 , 0.97), 0.95 (0.92 , 0.98), 0.96 (0.87 , 1.05) and 1.08 (1.02 , 1.14) kPa.L-1.second for never (n=482), early transient (n=236), late-onset (n=22) and persistent (n=98) wheezing phenotypes respectively. Additional analyses were performed for children with atopic and non-atopic mothers separately. Both in children with atopic and non-atopic mothers, children with persistent wheeze had significantly higher interrupter resistance values than children with never and early wheeze. In conclusion, mean interrupter resistance values were higher in children with persistent wheeze as compared to children with never and early transient wheezing phenotypes.
Key words: Asthma, Child preschool, Allergy, Cohort studies




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