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Published ahead of print on July 21, 2004, doi:10.1164/rccm.200305-617OC

Am. J. Respir. Crit. Care Med., Volume 170, Number 8, October 2004, 870-878

A more recent version of this article appeared on October 15, 2004
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Submitted on May 7, 2003
Accepted on July 15, 2004

Effects of Testosterone and Resistance Training in Men with Chronic Obstructive Pulonary Disease

Richard Casaburi1*, Shalender Bhasin2, Louis Cosentino1, Janos Porszasz1, Attila Somfay1, Michael I Lewis3, Mario Fournier3, and Thomas W Storer4

1 Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA, 2 Division of Endocrinology and Molecular Medicine, Drew University of Medicine and Science, Los Angeles, CA, USA, 3 Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Torrance, CA, USA, 4 Division of Endocrinology and Molecular Medicine, Drew University of Medicine and Science, Los Angeles, CA, USA; Exercise Sciences Laboratory, El Camino College, Torrance, CA, USA

* To whom correspondence should be addressed. E-mail: casaburi{at}ucla.edu.

Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels which may contribute to muscle weakness. We determined effects of testosterone supplementation (100mg testosterone enanthate injected weekly) with or without resistance training (45 minutes thrice weekly) on body composition and muscle function in 47 men with COPD (mean FEV1=40%pred.) and low testosterone levels (mean=320ng/dl). Subjects were randomized to 10 weeks of placebo injections+no training, testosterone injections+no training, placebo injections+resistance training or testosterone injections+resistance training. Testosterone injections yielded mean increase of 271ng/dl in nadir serum testosterone concentration (to the middle of the normal range for young men). Lean body mass (by dual energy x-ray absorptiometry) increase averaged 2.3kg with testosterone alone and 3.3kg with combined testosterone and resistance training (p<0.001). Increase in one-repetition maximum leg press strength averaged 17.2% with testosterone alone, 17.4% with resistance training alone and 26.8% with testosterone+resistance training (p<0.001). Interventions were well tolerated with no abnormalities in safety measures. Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels.
Key words: androgenic steroid, strength, inflammation, muscle mass




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