help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on October 2, 2003, doi:10.1164/rccm.200304-590OC

Am. J. Respir. Crit. Care Med., Volume 169, Number 2, January 2004, 163-167

A more recent version of this article appeared on January 15, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200304-590OCv1
169/2/163    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gozal, D.
Right arrow Articles by Burnside, M. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gozal, D.
Right arrow Articles by Burnside, M. M

Submitted on April 30, 2003
Accepted on September 27, 2003

Increased Upper Airway Collapsibility in Children with Obstructive Sleep Apnea During Wakefulness

David Gozal1* and Marilee M Burnside1

1 Division of Pediatric Sleep Medicine, University of Louisville and Kosair Children's Hospital Research Institute, Louisville, KY, USA

* To whom correspondence should be addressed. E-mail: david.gozal{at}louisville.edu.

Upper airway collapsibility is increased in children with sleep-disordered breathing (SDB), but during wakefulness active neural processes preserve upper airway patency, such that measurement of upper airway dynamics using acoustic pharyngometry may contribute to diagnostic accuracy in snoring children. Upper airway cross sectional area (CSA) measurements obtained from acoustic pharyngometry measurements was assessed iin 247 children referred for evaluation of suspected SDB and controls, before and after application of Cetacaine 1% spray to the pharyngeal introitus under visual inspection. Upper airway collapsibility (UAC) was determined from the % change in CSA after topical anesthesia. UAC measurements were reproducible 1-week apart in both controls and SDB patients (p<0.005). An UAC <=-30% exhibited high sensitivity and specificity in identification of all children with obstructive apnea-hypopnea index (AHI)>5 /hrTST in a prospective initial sample of 54 children and in a subsequent post-hoc sample of 94 snoring children. Thus, upper airway dynamic testing during wakefulness in response to a topical airway anesthetic may provide a useful clinical adjunct to the evaluation of snoring children, with more accurate identification of those children with SDB.
Key words: sleep disordered breathing; snoring; acoustic pharyngometry; topical anesthesia




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
E. S. Katz and C. M. D'Ambrosio
Pathophysiology of Pediatric Obstructive Sleep Apnea
Proceedings of the ATS, February 15, 2008; 5(2): 253 - 262.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
H. Muzumdar and R. Arens
Diagnostic Issues in Pediatric Obstructive Sleep Apnea
Proceedings of the ATS, February 15, 2008; 5(2): 263 - 273.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. D. Goldbart, J. Krishna, R. C. Li, L. D. Serpero, and D. Gozal
Inflammatory Mediators in Exhaled Breath Condensate of Children With Obstructive Sleep Apnea Syndrome.
Chest, July 1, 2006; 130(1): 143 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. S. Katz, C. L. Marcus, and D. P. White
Influence of Airway Pressure on Genioglossus Activity during Sleep in Normal Children
Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 902 - 909.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. I. Pack
Advances in Sleep-disordered Breathing
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 7 - 15.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
L. Kheirandish, A. D. Goldbart, and D. Gozal
Intranasal Steroids and Oral Leukotriene Modifier Therapy in Residual Sleep-Disordered Breathing After Tonsillectomy and Adenoidectomy in Children
Pediatrics, January 1, 2006; 117(1): e61 - e66.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Arens, S. Sin, J. M. McDonough, J. M. Palmer, T. Dominguez, H. Meyer, D. M. Wootton, and A. I. Pack
Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome
Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1298 - 1304.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. D. Bradley, Y. E. Miller, F. J. Martinez, D. C. Angus, W. MacNee, and E. Abraham
Interstitial Lung Disease, Lung Cancer, Lung Transplantation, Pulmonary Vascular Disorders, and Sleep-disordered Breathing in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 675 - 685.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. S. Katz and D. P. White
Genioglossus Activity During Sleep in Normal Control Subjects and Children with Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 553 - 560.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. L. Marcus
Evaluating the Upper Airway during Wakefulness: What Can It Tell Us about Sleep?
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 140 - 141.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  Tobacco