Published ahead of print on September 18, 2003, doi:10.1164/rccm.200303-363OC Am. J. Respir. Crit. Care Med., Volume 168, Number 12, December 2003, 1476-1480 A more recent version of this article appeared on December 15, 2003
Submitted on May 15, 2003 Muscle function and resting energy expenditure in female athletes with cystic fibrosisHiran C Selvadurai1*,1 Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada, 2 James Fairfax Institute for Nutrition, Childrens Hospital at Westmead, Sydney, NSW, Australia, 3 MRS Unit, Rayscan Radiology, Sydney, NSW, Australia, 4 Kinesiology, McMaster University, Hamilton, Ontario, Canada, 5 Respiratory Medicine, Childrens Hospital at Westmead, Sydney, NSW, Australia * To whom correspondence should be addressed. E-mail: hiran.selvadurai{at}sickkids.ca.
The pathophysiology of impaired exercise tolerance in patients with cystic fibrosis is not completely understood. The objective of this study was to compare exercise ability (at clinical and cellular levels) and resting energy expenditure in female athletes with CF compared with matched controls. Sixteen subjects and matched controls participated in the study. The girls with CF not only had a significantly greater resting energy expenditure (7.6% higher p<0.05), their habitual daily activity was also significantly greater than controls (15% greater, p<0.01). The peak aerobic capacity was similar in both groups. However, peak anaerobic power was 20% less (p<0.05) respectively, in girls with CF. The 31P MRS studies demonstrated that there were no differences between the group at rest, but at 25% total work output the girls with CF were less acidotic [pH 6.99 (0.06) CF, 6.90 (0.05) controls] and had a significantly lower inorganic phosphorus to phosphocreatine ratio [0.34 (0.07) CF, 0.41 (0.08) controls]. These differences continued to increase to maximal exercise. This study demonstrates that in spite of normal lung function and good nutritional status, females athletes with CF still had significant deficiencies in some measures of fitness and muscle metabolism compared to healthy athletes. Key words: muscle metabolism, energy stores, aerobic capacity, anaerobic power
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