Published ahead of print on November 14, 2003, doi:10.1164/rccm.200302-278OC
Am. J. Respir. Crit. Care Med., Volume 169, Number 5, March 2004, 615-622
A more recent version of this article appeared on March 1, 2004
Submitted on February 26, 2003
Accepted on November 14, 2003
Age-specific relationship between CD14 and atopy in a cohort assessed from age eight to twenty-five
Anne R O'Donnell1, Brett G Toelle2, Guy B Marks2, Catherine M Hayden1, Ingrid A Laing1, Jennifer K Peat2, Jack Goldblatt1, and Peter N Le Souef1*
1 Paediatrics, University of Western Australia, Children's Hospital Medical Centre, Perth, Western Australia, Australia,
2 The Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
* To whom correspondence should be addressed. E-mail: peterles{at}ichr.uwa.edu.au.
CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and immunoglobulin E levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected population with extensive longitudinal data was used to test the hypothesis that CD14 C-159T was associated with early onset atopy. Three hundred and five subjects were assessed on up to seven occasions between age eight and twenty-five years by questionnaire, histamine challenge and skin prick test. For atopy, airway hyperresponsiveness and wheeze, each subject was classified as having early, late or no disease onset during follow-up. Compared with subjects with -159CT and -159TT, subjects with -159CC had an odds ratio for early onset atopy of 2.2 (p=0.018) and for early onset airway hyperresponsiveness of 2.6 (p=0.019). Cross-sectional analysis showed increased prevalence of -159CC in subjects with atopy and airway hyperresponsiveness in childhood but not adulthood. These data suggest that the influence of CD14 -159C on the atopic phenotype may be age specific; exerting an effect during mid-childhood which is no longer apparent by early adulthood.
Key words: longitudinal, gene, polymorphism, asthma
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