Published ahead of print on July 3, 2003, doi:10.1164/rccm.200302-256OC
Am. J. Respir. Crit. Care Med., Volume 168, Number 6, September 2003, 677-684
A more recent version of this article appeared on September 15, 2003
Submitted on February 21, 2003
Accepted on June 30, 2003
EFFECT OF CORTICOSTEROID ON LUNG PARENCHYMA REMODELING AT AN EARLY PHASE OF ACUTE LUNG INJURY
Patricia R.M. Rocco1, Alba B Souza1, Debora S Faffe1, Caroline P Passaro1, Flavia B Santos1, Elnara M Negri2, Januario G.M. Lima1, Renata S Contador1, Vera L Capelozzi3, and Walter A Zin1*
1 Laboratory of Respiration Physiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil,
2 LIM59, University of Sao Paulo, Sao Paulo, Brazil,
3 Pathology and Clinical Emergencies, University of Sao Paulo, Sao Paulo, Brazil
* To whom correspondence should be addressed. E-mail: wazin{at}biof.ufrj.br.
In vivo [lung resistive and viscoelastic pressures, and static elastance] and in vitro [tissue resistance, elastance, and hysteresivity] respiratory mechanics were analyzed 1 and 30 days after saline (control) or paraquat [P (10 and 25 mg/kg, i.p.)] injection in rats. Additionally, P10 and P25 were treated with methylprednisolone (2 mg/kg, i.v.) at 1 or 6 hours after acute lung injury (ALI) induction. Collagen and elastic fibers were quantified. Lung resistive and viscoelastic pressures, and static elastance were higher in P10 and P25 than in control. Tissue elastance and resistance augmented from control to P10 (1 and 30 days) and P25. Hysteresivity increased only in P25. Methylprednisolone at 1 or 6 hours attenuated in vivo and in vitro mechanical changes in P25, while P10 parameters were similar to control. Collagen increment was dose- and time-dependent. Elastic fibers increased in P25, and at 30 days in P10. Corticosteroid prevented collagen increment, and avoided elastogenesis. In conclusion, methylprednisolone led to a complete maintenance of in vivo and in vitro respiratory mechanics in mild lesion, whereas minimized the changes in tissue impedance and extracellular matrix in severe ALI. The beneficial effects of the early use of steroids in ALI remained unaltered at day 30.
Key words: tissue mechanics, acute lung injury, corticosteroid, hysteresivity, elastin
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