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Published ahead of print on November 20, 2003, doi:10.1164/rccm.200301-055OC

Am. J. Respir. Crit. Care Med., Volume 169, Number 3, February 2004, 393-398

A more recent version of this article appeared on February 1, 2004
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Submitted on January 16, 2003
Accepted on November 12, 2003

Relation of Serum Antioxidants to Asthma Prevalence in Youth

Rachel N Rubin1, Livia Navon1, and Patricia A Cassano1*

1 Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA

* To whom correspondence should be addressed. E-mail: pac6{at}cornell.edu.

The relation of serum vitamin E, {beta}-carotene, vitamin C, and selenium to asthma was investigated among 7,505 youth (4-16 yrs) in the Third National Health and Nutrition Examination Survey. Logistic regression models adjusted for potentially confounding variables, which generally had no effect on the coefficients for the antioxidants. Serum vitamin E had little or no association with asthma. In separate models, a standard deviation (SD) increase in {beta}-carotene (odds ratios (OR) 0.9; 95% confidence intervals (CI) 0.7, 1.0), vitamin C (OR 0.8; 95% CI 0.7, 0.9) and selenium (OR 0.9; 95% CI 0.7, 1.1) was associated with a 10 to 20% reduction in asthma prevalence. Serum cotinine was used to identify youth with no cigarette smoke exposure and passive exposure (7%): active smokers were too few to be studied further. The selenium-asthma association was stronger in passively smoke exposed youth (p=0.075). A SD increase in selenium was associated with a 50% reduction in asthma prevalence (OR 0.5; 95% CI 0.2, 1.4) in passive smoke exposed youth, compared to a 10% reduction in youth with no smoke exposure. The findings support an association of antioxidants with prevalent asthma, which, for some antioxidants, is stronger among children exposed to cigarette smoke.
Key words: nutrition surveys, antioxidants, oxidative stress, asthma, child




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