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Published ahead of print on July 17, 2003, doi:10.1164/rccm.200212-1525OC

Am. J. Respir. Crit. Care Med., Volume 168, Number 9, November 2003, 1034-1042

A more recent version of this article appeared on November 1, 2003
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Submitted on December 31, 2002
Accepted on July 14, 2003

Benefits of supplemental oxygen in exercise training in non-hypoxemic COPD patients

Margareta Emtner1, Janos Porszasz2, Mary Burns2, Attila Somfay3, and Richard Casaburi2*

1 Rehabilitation Clinical Trials Center, Harbor-University of California Los Angeles Research and Education Institute, Torrance, CA, USA; Medical Sciences, Pulmonary Medicine and Allergology, University of Uppsala, Uppsala, Sweden, 2 Rehabilitation Clinical Trials Center, Harbor-University of California Los Angeles Research and Education Institute, Torrance, CA, USA, 3 Rehabilitation Clinical Trials Center, Harbor-University of California Los Angeles Research and Education Institute, Torrance, CA, USA; Pulmonology, Albert Szent-Gyorgyi Medical University, Szeged-Deszk, Hungary

* To whom correspondence should be addressed. E-mail: casaburi{at}ucla.edu.

Supplemental oxygen improves exercise tolerance of normoxemic and hypoxemic COPD patients. We determined whether non-hypoxemic COPD patients undergoing exercise training while breathing supplemental oxygen achieve higher intensity and therefore improve exercise capacity more than patients breathing air. A double-blinded trial was performed involving 29 non-hypoxemic patients (67 years, exercise SaO2>88%) with COPD (FEV1 =36 % pred). All exercised on cycle ergometers for 45 minutes, 3 times/week for 7 weeks at high intensity targets. During exercise they received oxygen (3 L/minute)(n=14) or compressed air (3 L/minute)(n=15). Both groups had higher exercise tolerance after training and when breathing oxygen. However, the oxygen trained group increased training work rate more rapidly than the air trained group. Mean (±SD) work rate during the last week was 62±19 Watts (oxygen trained group) and 52±22 Watts (air trained group) (p < 0.01). After training, endurance in constant work rate tests increased more in oxygen trained group (14.5 minutes) than in air trained group (10.5 minutes) (p<0.05). At isotime, breathing rate decreased 4 breaths/minute in oxygen trained group and 1 breath/minute in air trained group (p=0.001). We conclude that supplemental oxygen provided during high-intensity training yields higher training intensity and evidence of gains in exercise tolerance in laboratory testing.
Key words: chronic obstructive pulmonary disease, pulmonary rehabilitation, dyspnea




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