help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on May 28, 2003, doi:10.1164/rccm.200211-1311OC

Am. J. Respir. Crit. Care Med., Volume 168, Number 5, September 2003, 538-542

A more recent version of this article appeared on September 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200211-1311OCv1
168/5/538    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Collard, H. R
Right arrow Articles by Brown, K. K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Collard, H. R
Right arrow Articles by Brown, K. K

Submitted on November 11, 2002
Accepted on May 15, 2003

CHANGES IN CLINICAL AND PHYSIOLOGIC VARIABLES PREDICT SURVIVAL IN IDIOPATHIC PULMONARY FIBROSIS

Harold R Collard1, Talmadge E King, Jr.2, Becki Bucher Bartelson3, Jason S Vourlekis4, Marvin I Schwarz1, and Kevin K Brown4*

1 Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA, 2 Medicine, University of California at San Francisco, San Francisco General Hospital, San Francisco, CA, USA, 3 Biostatistics and Clinical Studies, NetRegulus, Centennial, CO, USA, 4 Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA; Medicine, National Jewish Medical and Research Center, Denver, CO, USA

* To whom correspondence should be addressed. E-mail: brownk{at}njc.org.

There is significant heterogeneity in survival time among patients with Idiopathic Pulmonary Fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive value of changes in clinical and physiological variables over time for survival time in 81 patients with biopsy-proven Idiopathic Pulmonary Fibrosis. Six month changes in dyspnea score, total lung capacity, thoracic gas volume, forced vital capacity, forced expiratory volume in one second, diffusing capacity of carbon monoxide, partial pressure of arterial oxygen, oxygen saturation and alveolar-arterial oxygen gradient were predictive of survival time even after adjustment for baseline values. Analyses were repeated on 51 patients with 12 month change data. Twelve month changes in dyspnea score, total lung capacity, forced vital capacity, partial pressure of arterial oxygen, oxygen saturation and alveolar-arterial oxygen gradient were predictive of survival time after adjustment for baseline values. Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone.
Key words: interstitial lung disease, pulmonary fibrosis, survival




This article has been cited by other articles:


Home page
 ThoraxHome page
A U Wells, N Hirani, and on behalf of the British Thoracic Society Intersti
Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society
Thorax, September 1, 2008; 63(Suppl_V): v1 - v58.
[Full Text] [PDF]

Home page
 RadiologyHome page
K. M. Shin, K. S. Lee, M. P. Chung, J. Han, Y. A Bae, T. S. Kim, and M. J. Chung
Prognostic Determinants among Clinical, Thin-Section CT, and Histopathologic Findings for Fibrotic Idiopathic Interstitial Pneumonias: Tertiary Hospital Study
Radiology, August 5, 2008; (2008) 2483071378.
[Abstract] [Full Text]

Home page
 Eur Respir JHome page
M. K. Han, S. Murray, C. D. Fell, K. R. Flaherty, G. B. Toews, J. Myers, T. V. Colby, W. D. Travis, E. A. Kazerooni, B. H. Gross, et al.
Sex differences in physiological progression of idiopathic pulmonary fibrosis
Eur. Respir. J., June 1, 2008; 31(6): 1183 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A E Holland, C J Hill, M Conron, P Munro, and C F McDonald
Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease
Thorax, June 1, 2008; 63(6): 549 - 554.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
W A Wuyts, M Thomeer, L J Dupont, and G M Verleden
An algorithm for referral of patients with IPF for lung transplantation
Thorax, March 1, 2008; 63(3): 292 - 292.
[Full Text] [PDF]

Home page
 ChestHome page
B. W. Kinder, K. K. Brown, M. I. Schwarz, J. H. Ix, A. Kervitsky, and T. E. King Jr
Baseline BAL Neutrophilia Predicts Early Mortality in Idiopathic Pulmonary Fibrosis
Chest, January 1, 2008; 133(1): 226 - 232.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
L. S Mackay, R. L Anderson, G. Parry, J. Lordan, P. A Corris, and A. J Fisher
Pulmonary fibrosis: rate of disease progression as a trigger for referral for lung transplantation
Thorax, December 1, 2007; 62(12): 1069 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. H. T. Bates, G. S. Davis, A. Majumdar, K. J. Butnor, and B. Suki
Linking Parenchymal Disease Progression to Changes in Lung Mechanical Function by Percolation
Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 617 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
K. K. Brown
Roger S. Mitchell Lecture. Rheumatoid Lung Disease
Proceedings of the ATS, August 15, 2007; 4(5): 443 - 448.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
I. Noth and F. J. Martinez
Recent Advances in Idiopathic Pulmonary Fibrosis
Chest, August 1, 2007; 132(2): 637 - 650.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. D. Nathan, P. W. Noble, and R. M. Tuder
Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Connecting the Dots
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 875 - 880.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Alakhras, P. A. Decker, H. F. Nadrous, M. Collazo-Clavell, and J. H. Ryu
Body Mass Index and Mortality in Patients With Idiopathic Pulmonary Fibrosis
Chest, May 1, 2007; 131(5): 1448 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. U. Wells and C. M. Hogaboam
Update in Diffuse Parenchymal Lung Disease 2006
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 655 - 660.
[Full Text] [PDF]

Home page
 ChestHome page
K. Hamada, S. Nagai, S. Tanaka, T. Handa, M. Shigematsu, T. Nagao, M. Mishima, M. Kitaichi, and T. Izumi
Significance of Pulmonary Arterial Pressure and Diffusion Capacity of the Lung as Prognosticator in Patients With Idiopathic Pulmonary Fibrosis
Chest, March 1, 2007; 131(3): 650 - 656.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
O.J. Dempsey, K.M. Kerr, L. Gomersall, H. Remmen, and G.P. Currie
Idiopathic pulmonary fibrosis: an update
QJM, October 1, 2006; 99(10): 643 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. R. Flaherty, A.-C. Andrei, S. Murray, C. Fraley, T. V. Colby, W. D. Travis, V. Lama, E. A. Kazerooni, B. H. Gross, G. B. Toews, et al.
Idiopathic Pulmonary Fibrosis: Prognostic Value of Changes in Physiology and Six-Minute-Walk Test
Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 803 - 809.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. J. Lederer, S. M. Arcasoy, J. S. Wilt, F. D'Ovidio, J. R. Sonett, and S. M. Kawut
Six-Minute-Walk Distance Predicts Waiting List Survival in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., September 15, 2006; 174(6): 659 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. M. Antoniou, A. G. Nicholson, M. Dimadi, K. Malagari, P. Latsi, A. Rapti, N. Tzanakis, R. Trigidou, V. Polychronopoulos, and D. Bouros
Long-term clinical effects of interferon gamma-1b and colchicine in idiopathic pulmonary fibrosis
Eur. Respir. J., September 1, 2006; 28(3): 496 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Martinez and M. P. Keane
Update in diffuse parenchymal lung diseases 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1066 - 1071.
[Full Text] [PDF]

Home page
 ChestHome page
G. Raghu, S. T.-Y. Yang, C. Spada, J. Hayes, and C. A. Pellegrini
Sole Treatment of Acid Gastroesophageal Reflux in Idiopathic Pulmonary Fibrosis: A Case Series
Chest, March 1, 2006; 129(3): 794 - 800.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Pignatti, G. Brunetti, D. Moretto, M.-R. Yacoub, M. Fiori, B. Balbi, A. Balestrino, G. Cervio, S. Nava, and G. Moscato
Role of the Chemokine Receptors CXCR3 and CCR4 in Human Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., February 1, 2006; 173(3): 310 - 317.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
F. J. Martinez
Idiopathic Interstitial Pneumonias: Usual Interstitial Pneumonia versus Nonspecific Interstitial Pneumonia.
Proceedings of the ATS, January 1, 2006; 3(1): 81 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. S. Kim, H. R. Collard, and T. E. King Jr.
Classification and natural history of the idiopathic interstitial pneumonias.
Proceedings of the ATS, January 1, 2006; 3(4): 285 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
F. J. Martinez and K. Flaherty
Pulmonary function testing in idiopathic interstitial pneumonias.
Proceedings of the ATS, January 1, 2006; 3(4): 315 - 321.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. Demedts, J. Behr, R. Buhl, U. Costabel, R. Dekhuijzen, H. M. Jansen, W. MacNee, M. Thomeer, B. Wallaert, F. Laurent, et al.
High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis.
N. Engl. J. Med., November 24, 2005; 353(21): 2229 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W. C. Johnson and G. Raghu
Clinical trials in idiopathic pulmonary fibrosis: a word of caution concerning choice of outcome measures
Eur. Respir. J., November 1, 2005; 26(5): 755 - 758.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Pellegrino, G. Viegi, V. Brusasco, R. O. Crapo, F. Burgos, R. Casaburi, A. Coates, C. P. M. van der Grinten, P. Gustafsson, J. Hankinson, et al.
Interpretative strategies for lung function tests
Eur. Respir. J., November 1, 2005; 26(5): 948 - 968.
[Full Text] [PDF]

Home page
 ChestHome page
S. D. Nathan
Therapeutic Intervention: Assessing the Role of the International Consensus Guidelines
Chest, November 1, 2005; 128(5_suppl_1): 533S - 539S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
H. F. Nadrous, P. A. Pellikka, M. J. Krowka, K. L. Swanson, N. Chaowalit, P. A. Decker, and J. H. Ryu
Pulmonary Hypertension in Patients With Idiopathic Pulmonary Fibrosis
Chest, October 1, 2005; 128(4): 2393 - 2399.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
M. A Pacanowski and G. W Amsden
Interferon Gamma-1b in the Treatment of Idiopathic Pulmonary Fibrosis
Ann. Pharmacother., October 1, 2005; 39(10): 1678 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Eaton, P. Young, D. Milne, and A. U. Wells
Six-Minute Walk, Maximal Exercise Tests: Reproducibility in Fibrotic Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1150 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. du Bois
Is Idiopathic Pulmonary Fibrosis Now Treatable?
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 939 - 940.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Azuma, T. Nukiwa, E. Tsuboi, M. Suga, S. Abe, K. Nakata, Y. Taguchi, S. Nagai, H. Itoh, M. Ohi, et al.
Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1040 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Ito, S. Nagai, M. Kitaichi, A. G. Nicholson, T. Johkoh, S. Noma, D. S. Kim, T. Handa, T. Izumi, and M. Mishima
Pulmonary Manifestations of Primary Sjogren's Syndrome: A Clinical, Radiologic, and Pathologic Study
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 632 - 638.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Jegal, D. S. Kim, T. S. Shim, C.-M. Lim, S. Do Lee, Y. Koh, W. S. Kim, W. D. Kim, J. S. Lee, W. D. Travis, et al.
Physiology Is a Stronger Predictor of Survival than Pathology in Fibrotic Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 639 - 644.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. D. Nathan
Lung Transplantation: Disease-Specific Considerations for Referral
Chest, March 1, 2005; 127(3): 1006 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. S. Hallstrand, L. J. Boitano, W. C. Johnson, C. A. Spada, J. G. Hayes, and G. Raghu
The timed walk test as a measure of severity and survival in idiopathic pulmonary fibrosis
Eur. Respir. J., January 1, 2005; 25(1): 96 - 103.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
T. E. King Jr, S. Safrin, K. M. Starko, K. K. Brown, P. W. Noble, G. Raghu, and D. A. Schwartz
Analyses of Efficacy End Points in a Controlled Trial of Interferon-{gamma}1b for Idiopathic Pulmonary Fibrosis
Chest, January 1, 2005; 127(1): 171 - 177.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
N. Khalil and R. O'Connor
Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment
Can. Med. Assoc. J., July 20, 2004; 171(2): 153 - 160.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
H. R. Collard, J. H. Ryu, W. W. Douglas, M. I. Schwarz, D. Curran-Everett, T. E. King Jr., and K. K. Brown
Combined Corticosteroid and Cyclophosphamide Therapy Does Not Alter Survival in Idiopathic Pulmonary Fibrosis
Chest, June 1, 2004; 125(6): 2169 - 2174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Thabut, M. Fournier, H. R. Collard, and K. K. Brown
Prognosis in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1075 - 1076.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Tuberculosis, Lung Infections, Interstitial Lung Disease, Social Issues and Journalology in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 288 - 300.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. W. Noble and D. G. Morris
Time Will Tell: Predicting Survival in Idiopathic Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 510 - 511.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society