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Published ahead of print on September 18, 2003, doi:10.1164/rccm.200210-1234OC

Am. J. Respir. Crit. Care Med., Volume 169, Number 1, January 2004, 27-33

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Submitted on November 5, 2002
Accepted on September 13, 2003

Laminin-5 {gamma}2 Chain in Cryptogenic Organizing Pneumonia and Idiopathic Pulmonary Fibrosis

Elisa Lappi-Blanco1*, Riitta Kaarteenaho-Wiik2, Sirpa Salo3, Raija Sormunen4, Marko Maatta5, Helena Autio-Harmainen6, Ylermi Soini1, and Paavo Paakko6

1 Pathology, University of Oulu, Oulu, Finland; Pathology, Oulu University Hospital, Oulu, Finland, 2 Internal Medicine, Oulu University Hospital, Oulu, Finland, 3 Biochemistry, University of Oulu, Oulu, Finland, 4 Biocenter Oulu, Oulu, Finland; Pathology, University of Oulu, Oulu, Finland, 5 Pathology, University of Oulu, Oulu, Finland, 6 Pathology, Oulu University Hospital, Oulu, Finland; Pathology, University of Oulu, Oulu, Finland

* To whom correspondence should be addressed. E-mail: elisa.lappi-blanco{at}oulu.fi.

Insufficient re-epithelialization of injured alveolar walls is suspected to be important in the pathogenesis of IPF. Laminin-5 is expressed in epithelial cells of healing wounds promoting cell attachment and migration. In this study we have studied the extent of re-epithelialization of newly formed intraluminal connective tissue, the immunohistochemical expression and ultrastructural localization of laminin-5 {gamma}2 chain protein, and the synthesis of laminin-5 {gamma}2 chain mRNA in regenerating epithelial cells in cryptogenic organizing pneumonia (COP) and idiopathic pulmonary fibrosis (IPF). The results show that the mean extent of re-epithelialization of intraluminal connective tissue lesions was 76 % (SD ± 27 %) in COP, and 54 % (SD ±23 %) in IPF (p<0.025). The laminin-5 {gamma}2 chain was synthesized and widely expressed in regenerating epithelial cells in both diseases. Immunohistochemistry for surfactant-associated protein A suggests a pneumocyte origin for the regenerating epithelial cells in IPF. It is concluded that both in COP and IPF, the regenerating epithelial cells are capable of synthesizing the laminin-5 {gamma}2 chain needed for adhesive connections to the underlying BM. However, in IPF, the re-epithelialization seems to be disturbed or delayed.
Key words: pulmonary fibrosis, COP, IPF, laminin-5, alveolar epithelium




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