help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on January 24, 2003, doi:10.1164/rccm.200210-1157BC

Am. J. Respir. Crit. Care Med., Volume 167, Number 8, April 2003, 1139-1141

A more recent version of this article appeared on April 15, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200210-1157BCv1
167/8/1139    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ghofrani, H. A
Right arrow Articles by Grimminger, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ghofrani, H. A
Right arrow Articles by Grimminger, F.

Submitted on October 12, 2002
Accepted on January 21, 2003

Sildenafil for long-term treatment of non-operable chronic thromboembolic pulmonary hypertension

Hossein A Ghofrani1, Ralph T Schermuly1, Frank Rose1, Ralph Wiedemann1, Markus G Kohstall1, Andre Kreckel1, Horst Olschewski1, Norbert Weissmann1, Beate Enke1, Stefanie Ghofrani1, Werner Seeger1, and Friedrich Grimminger1*

1 Internal Medicine, University Hospital, Justus-Liebig University Giessen, Giessen, Germany

* To whom correspondence should be addressed. E-mail: friedrich.grimminger{at}innere.med.uni-giessen.de.

Only a small percentage of patients with chronic thromboembolic pulmonary hypertension (CTEPH) are eligible for pulmonary thrombendarterectomy. We investigated the effects of oral sildenafil on hemodynamics and exercise capacity in 12 non-operable CTEPH patients. All patients were in disease progression despite sufficient long-term anticoagulation and best supportive care, and suffered from severe pulmonary hypertension (pulmonary vascular resistance index (PVRI) 1935+/-228 dyn*s*cm-5*m2, cardiac index (CI) 2.0 l*min-1*m-2, 6-min-walking distance 312+/-30 m). After approximately 6 months of sildenafil treatment, pulmonary hemodynamics and exercise capacity improved significantly (PVRI 1361+/-177 l*min-1*m2 (p=0.004), CI 2.4+/-0.2 l*min-1*m-2 (p=0.009), 6-minute-walking distance 366+/-28 m (p=0.02)). Therefore, oral sildenafil may offer a new option for medical treatment of this devastating disease.
Key words: Pulmonary hypertension, chronic thromboembolism, phosphodiesterase inhibitor, sildenafil




This article has been cited by other articles:


Home page
 J Clin PharmacolHome page
E. Gruenig, E. Michelakis, J.-L. Vachiery, C. D. Vizza, F. J. Meyer, M. Doelberg, D. Bach, J. Dingemanse, and N. Galie
Acute Hemodynamic Effects of Single-Dose Sildenafil When Added to Established Bosentan Therapy in Patients With Pulmonary Arterial Hypertension: Results of the COMPASS-1 Study
J. Clin. Pharmacol., November 1, 2009; 49(11): 1343 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J.-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
Eur. Heart J., October 2, 2009; 30(20): 2493 - 2537.
[Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
N. Galiè and A. Manes
CHAPTER 24 Pulmonary Hypertension
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Rich and M. Rabinovitch
Diagnosis and Treatment of Secondary (Non-Category 1) Pulmonary Hypertension
Circulation, November 18, 2008; 118(21): 2190 - 2199.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
R. T. Schermuly, J-P. Stasch, S. S. Pullamsetti, R. Middendorff, D. Muller, K-D. Schluter, A. Dingendorf, S. Hackemack, E. Kolosionek, C. Kaulen, et al.
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Eur. Respir. J., October 1, 2008; 32(4): 881 - 891.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. H. Freed, B. M. Thomson, S. S.L. Tsui, J. J. Dunning, K. K. Sheares, J. Pepke-Zaba, and D. P. Jenkins
Functional and haemodynamic outcome 1 year after pulmonary thromboendarterectomy
Eur. J. Cardiothorac. Surg., September 1, 2008; 34(3): 525 - 530.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. S. Hill, I. R. Preston, and K. E. Roberts
Inoperable Chronic Thromboembolic Pulmonary Hypertension: Treatable With Medical Therapy
Chest, August 1, 2008; 134(2): 221 - 223.
[Full Text] [PDF]

Home page
 ChestHome page
J. Suntharalingam, C. M. Treacy, N. J. Doughty, K. Goldsmith, E. Soon, M. R. Toshner, K. K. Sheares, R. Hughes, N. W. Morrell, and J. Pepke-Zaba
Long-term Use of Sildenafil in Inoperable Chronic Thromboembolic Pulmonary Hypertension
Chest, August 1, 2008; 134(2): 229 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. R. Wilkins, J. Wharton, F. Grimminger, and H. A. Ghofrani
Phosphodiesterase inhibitors for the treatment of pulmonary hypertension
Eur. Respir. J., July 1, 2008; 32(1): 198 - 209.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Condliffe, D. G. Kiely, J. S. R. Gibbs, P. A. Corris, A. J. Peacock, D. P. Jenkins, D. Hodgkins, K. Goldsmith, R. J. Hughes, K. Sheares, et al.
Improved Outcomes in Medically and Surgically Treated Chronic Thromboembolic Pulmonary Hypertension
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1122 - 1127.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Heart, March 1, 2008; 94(Suppl_1): i1 - i41.
[Full Text] [PDF]

Home page
 ThoraxHome page
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Thorax, March 1, 2008; 63(Suppl_2): ii1 - ii41.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Reichenberger, R. Voswinckel, B. Enke, M. Rutsch, E. El Fechtali, T. Schmehl, H. Olschewski, R. Schermuly, N. Weissmann, H. A. Ghofrani, et al.
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension
Eur. Respir. J., November 1, 2007; 30(5): 922 - 927.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J. Suntharalingam, R. D Machado, L. D Sharples, M. R Toshner, K. K Sheares, R. J Hughes, D. P Jenkins, R. C Trembath, N. W Morrell, and J. Pepke-Zaba
Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension
Thorax, July 1, 2007; 62(7): 617 - 622.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
S. Takaoka, J. L. Faul, and R. Doyle
Current Therapies for Pulmonary Arterial Hypertension
Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2007; 11(2): 137 - 148.
[Abstract] [PDF]

Home page
 CirculationHome page
R. T. Schermuly, S. S. Pullamsetti, G. Kwapiszewska, R. Dumitrascu, X. Tian, N. Weissmann, H. A. Ghofrani, C. Kaulen, T. Dunkern, C. Schudt, et al.
Phosphodiesterase 1 Upregulation in Pulmonary Arterial Hypertension: Target for Reverse-Remodeling Therapy
Circulation, May 1, 2007; 115(17): 2331 - 2339.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Fesler, A. Pagnamenta, B. Rondelet, F. Kerbaul, and R. Naeije
Effects of sildenafil on hypoxic pulmonary vascular function in dogs
J Appl Physiol, October 1, 2006; 101(4): 1085 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. A. Ghofrani, R. Voswinckel, F. Reichenberger, N. Weissmann, R. T. Schermuly, W. Seeger, and F. Grimminger
Hypoxia- and non-hypoxia-related pulmonary hypertension - Established and new therapies
Cardiovasc Res, October 1, 2006; 72(1): 30 - 40.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Ulrich, M. Fischler, R. Speich, V. Popov, and M. Maggiorini
Chronic thromboembolic and pulmonary arterial hypertension share acute vasoreactivity properties.
Chest, September 1, 2006; 130(3): 841 - 846.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. Galie and N. H. S. Kim
Pulmonary Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension
Proceedings of the ATS, September 1, 2006; 3(7): 571 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. Bresser, J. Pepke-Zaba, X. Jais, M. Humbert, and M. M. Hoeper
Medical Therapies for Chronic Thromboembolic Pulmonary Hypertension: An Evolving Treatment Paradigm
Proceedings of the ATS, September 1, 2006; 3(7): 594 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. J. Hughes, X. Jais, D. Bonderman, J. Suntharalingam, M. Humbert, I. Lang, G. Simonneau, and J. Pepke-Zaba
The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study
Eur. Respir. J., July 1, 2006; 28(1): 138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
I. Lang, M. Gomez-Sanchez, M. Kneussl, R. Naeije, P. Escribano, N. Skoro-Sajer, and J.-L. Vachiery
Efficacy of Long-term Subcutaneous Treprostinil Sodium Therapy in Pulmonary Hypertension
Chest, June 1, 2006; 129(6): 1636 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. M. Hoeper, E. Mayer, G. Simonneau, and L. J. Rubin
Chronic Thromboembolic Pulmonary Hypertension
Circulation, April 25, 2006; 113(16): 2011 - 2020.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Murata, K. Kinoshita, M. Hori, M. Kuwahara, H. Tsubone, H. Karaki, and H. Ozaki
Statin Protects Endothelial Nitric Oxide Synthase Activity in Hypoxia-Induced Pulmonary Hypertension
Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2335 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. M. Hoeper, T. Kramm, H. Wilkens, C. Schulze, H. J. Schafers, T. Welte, and E. Mayer
Bosentan Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension
Chest, October 1, 2005; 128(4): 2363 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Bonderman, R. Nowotny, N. Skoro-Sajer, J. Jakowitsch, C. Adlbrecht, W. Klepetko, and I. M. Lang
Bosentan Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension
Chest, October 1, 2005; 128(4): 2599 - 2603.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
L. J. Rubin and D. B. Badesch
Evaluation and Management of the Patient with Pulmonary Arterial Hypertension
Ann Intern Med, August 16, 2005; 143(4): 282 - 292.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A A Aldashev, B K Kojonazarov, T A Amatov, T M Sooronbaev, M M Mirrakhimov, N W Morrell, J Wharton, and M R Wilkins
Phosphodiesterase type 5 and high altitude pulmonary hypertension
Thorax, August 1, 2005; 60(8): 683 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Wharton, J. W. Strange, G. M. O. Moller, E. J. Growcott, X. Ren, A. P. Franklyn, S. C. Phillips, and M. R. Wilkins
Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 105 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. A. Dias-Junior, D. C. Souza-Costa, T. Zerbini, J. B. T. da Rocha, R. F. Gerlach, and J. E. Tanus-Santos
The Effect of Sildenafil on Pulmonary Embolism-Induced Oxidative Stress and Pulmonary Hypertension
Anesth. Analg., July 1, 2005; 101(1): 115 - 120.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. Ng, S. J. Finney, R. Shulman, G. J. Bellingan, M. Singer, and P. A. Glynne
Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?
Br. J. Anaesth., June 1, 2005; 94(6): 774 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-P. Richalet, P. Gratadour, P. Robach, I. Pham, M. Dechaux, A. Joncquiert-Latarjet, P. Mollard, J. Brugniaux, and J. Cornolo
Sildenafil Inhibits Altitude-induced Hypoxemia and Pulmonary Hypertension
Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 275 - 281.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Task Force members, N. Galie, A. Torbicki, R. Barst, P. Dartevelle, S. Haworth, T. Higenbottam, H. Olschewski, A. Peacock, G. Pietra, et al.
Guidelines on diagnosis and treatment of pulmonary arterial hypertension: The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology
Eur. Heart J., December 2, 2004; 25(24): 2243 - 2278.
[Full Text] [PDF]

Home page
 CirculationHome page
B. Rondelet, F. Kerbaul, R. Van Beneden, S. Motte, P. Fesler, I. Hubloue, M. Remmelink, S. Brimioulle, I. Salmon, J.-M. Ketelslegers, et al.
Signaling Molecules in Overcirculation-Induced Pulmonary Hypertension in Piglets: Effects of Sildenafil Therapy
Circulation, October 12, 2004; 110(15): 2220 - 2225.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. G. Raja and S. H. Nayak
Sildenafil: Emerging Cardiovascular Indications
Ann. Thorac. Surg., October 1, 2004; 78(4): 1496 - 1506.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Murata, M. Hori, K. Sakamoto, H. Karaki, and H. Ozaki
Dexamethasone Blocks Hypoxia-induced Endothelial Dysfunction in Organ-cultured Pulmonary Arteries
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 647 - 655.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
H. A. Ghofrani, F. Reichenberger, M. G. Kohstall, E. H. Mrosek, T. Seeger, H. Olschewski, W. Seeger, and F. Grimminger
Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial
Ann Intern Med, August 3, 2004; 141(3): 169 - 177.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
L. J. Rubin and R. Naeije
Sildenafil for Enhanced Performance at High Altitude?
Ann Intern Med, August 3, 2004; 141(3): 233 - 235.
[Full Text] [PDF]

Home page
 ChestHome page
W.-R. Chou, P.-H. Kuo, J.-C. Shih, and P.-C. Yang
A 31-Year-Old Pregnant Woman With Progressive Exertional Dyspnea and Differential Cyanosis
Chest, August 1, 2004; 126(2): 638 - 641.
[Full Text] [PDF]

Home page
 ChestHome page
D. B. Badesch, S. H. Abman, G. S. Ahearn, R. J. Barst, D. C. McCrory, G. Simonneau, and V. V. McLaughlin
Medical Therapy For Pulmonary Arterial Hypertension: ACCP Evidence-Based Clinical Practice Guidelines
Chest, July 1, 2004; 126(1_suppl): 35S - 62S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. L. Doyle, D. McCrory, R. N. Channick, G. Simonneau, and J. Conte
Surgical Treatments/Interventions for Pulmonary Arterial Hypertension: ACCP Evidence-Based Clinical Practice Guidelines
Chest, July 1, 2004; 126(1_suppl): 63S - 71S.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. A. Ghofrani, J. Pepke-Zaba, J. A. Barbera, R. Channick, A. M. Keogh, M. A. Gomez-Sanchez, M. Kneussl, and F. Grimminger
Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension
J. Am. Coll. Cardiol., June 16, 2004; 43(12_Suppl_S): 68S - 72S.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Bresser, P.F. Fedullo, W.R. Auger, R.N. Channick, I.M. Robbins, K.M. Kerr, S.W. Jamieson, and L.J. Rubin
Continuous intravenous epoprostenol for chronic thromboembolic pulmonary hypertension
Eur. Respir. J., April 1, 2004; 23(4): 595 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 301 - 313.
[Full Text] [PDF]

Home page
 CirculationHome page
N. H.S. Kim, P. Fesler, R. N. Channick, K. U. Knowlton, O. Ben-Yehuda, S. H. Lee, R. Naeije, and L. J. Rubin
Preoperative Partitioning of Pulmonary Vascular Resistance Correlates With Early Outcome After Thromboendarterectomy for Chronic Thromboembolic Pulmonary Hypertension
Circulation, January 6, 2004; 109(1): 18 - 22.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  SOTA, FL