help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on November 27, 2002, doi:10.1164/rccm.200209-1116OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 9, May 2003, 1232-1238

A more recent version of this article appeared on May 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200209-1116OCv1
167/9/1232    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Currie, G. P
Right arrow Articles by Lipworth, B. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Currie, G. P
Right arrow Articles by Lipworth, B. J

Submitted on October 3, 2002
Accepted on November 25, 2002

Effects of montelukast on surrogate inflammatory markers in corticosteroid treated asthmatics

Graeme P Currie1, Daniel K Lee1, Kay Haggart1, Caroline E Bates1, and Brian J Lipworth1*

1 Asthma and Allergy Research Group, Ninewells Hospital and Medical School,University of Dundee, Dundee, Scotland, United Kingdom

* To whom correspondence should be addressed. E-mail: b.j.lipworth{at}dundee.ac.uk.

We evaluated whether montelukast conferred additive effects in asthmatics receiving fluticasone/salmeterol (FP/SM) combination and fluticasone (FP) alone. Twenty-two mild-to-moderate asthmatics completed a double blind placebo-controlled study. After a 2-week run-in using FP 250µg/SM 50µg 1 puff BID, patients entered a randomised crossover period to receive additional montelukast 10mg daily or placebo for 3-weeks each. For the 1st 2-weeks they received FP/SM 1 puff BID then FP 250µg 1 puff BID for the 3rd week. The primary outcome was adenosine monophosphate (AMP) challenge threshold and recovery time; secondary outcomes included surrogate inflammatory markers and lung function. Compared to FP/SM run-in, adding montelukast to FP/SM was better (p<0.05) than placebo for inflammatory markers but not lung function. For AMP threshold, recovery, exhaled nitric oxide and blood eosinophils there were (95% CI) 1.4 (1.1-1.8) geometric mean fold, 10 (3-17) minute, 2.1 (0.2-3.9) ppb and 88 (34-172) x106/L differences respectively. The combination of FP plus montelukast was superior to FP/SM for inflammatory markers but inferior for lung function. Thus, in patients taking FP/SM or FP, montelukast conferred complimentary effects upon surrogate inflammatory markers, which were dissociated from lung function. Further studies are required to evaluate whether these effects of montelukast translate into clinical benefits.
Key words: leukotriene receptor antagonist, fluticasone, salmeterol, asthma therapy




This article has been cited by other articles:


Home page
 Therapeutic Advances in Respiratory DiseaseHome page
L. Bjermer
Review: Evaluating combination therapies for asthma: pros, cons, and comparative benefits
Therapeutic Advances in Respiratory Disease, June 1, 2008; 2(3): 149 - 161.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Deykin, M. E. Wechsler, H. A. Boushey, V. M. Chinchilli, S. J. Kunselman, T. J. Craig, E. DiMango, J. V. Fahy, M. Kraft, F. Leone, et al.
Combination Therapy with a Long-Acting beta-Agonist and a Leukotriene Antagonist in Moderate Asthma
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 228 - 234.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. P. Currie, D. K. C. Lee, D. Menzies, and B. J. Lipworth
Evaluating the Effects of "Triple Therapy" With Inhaled Corticosteroids, Long-Acting {beta}2-Agonists, and Leukotriene Modifiers in Asthma.
Chest, July 1, 2006; 130(1): 301 - 302.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
M. R. Zeidler, E. C. Kleerup, J. G. Goldin, H. J. Kim, D. A. Truong, M. D. Simmons, J. W. Sayre, W. Liu, R. Elashoff, and D. P. Tashkin
Montelukast improves regional air-trapping due to small airways obstruction in asthma
Eur. Respir. J., February 1, 2006; 27(2): 307 - 315.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
W. A. Biernacki, S. A. Kharitonov, H. M. Biernacka, and P. J. Barnes
Effect of Montelukast on Exhaled Leukotrienes and Quality of Life in Asthmatic Patients
Chest, October 1, 2005; 128(4): 1958 - 1963.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. P. Currie, D. K. C. Lee, and P. Srivastava
Long-Acting Bronchodilator or Leukotriene Modifier as Add-on Therapy to Inhaled Corticosteroids in Persistent Asthma?
Chest, October 1, 2005; 128(4): 2954 - 2962.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. C. Fardon and B. J. Lipworth
An Own GOAL or a Real Breakthrough?
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1060 - 1060.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. P. Currie and D. K. C. Lee
The GOAL Study Designed to Favor a Long-acting {beta}2-Agonist?
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1060 - 1061.
[Full Text] [PDF]

Home page
 BMJHome page
G. P Currie, G. S Devereux, D. K C Lee, and J. G Ayres
Recent developments in asthma management
BMJ, March 12, 2005; 330(7491): 585 - 589.
[Full Text] [PDF]

Home page
 QJMHome page
G.P. Currie, P. Srivastava, O.J. Dempsey, and D.K.C. Lee
Therapeutic modulation of allergic airways disease with leukotriene receptor antagonists
QJM, March 1, 2005; 98(3): 171 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Jayaram, M. Duong, M. M. M. Pizzichini, E. Pizzichini, D. Kamada, A. Efthimiadis, and F. E. Hargreave
Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma
Eur. Respir. J., January 1, 2005; 25(1): 41 - 46.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G.P. Currie and D.K.C. Lee
Methacholine and macrolides
Eur. Respir. J., October 1, 2004; 24(4): 709 - 710.
[Full Text] [PDF]

Home page
 ChestHome page
S. Steinshamn, M. Sandsund, M. Sue-Chu, and L. Bjermer
Effects of Montelukast and Salmeterol on Physical Performance and Exercise Economy in Adult Asthmatics With Exercise-Induced Bronchoconstriction
Chest, October 1, 2004; 126(4): 1154 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. S. Mendes, M. A. Campos, A. Hurtado, and A. Wanner
Effect of Montelukast and Fluticasone Propionate on Airway Mucosal Blood Flow in Asthma
Am. J. Respir. Crit. Care Med., May 15, 2004; 169(10): 1131 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. K. C. Lee, C. M. Jackson, K. Haggart, and B. J. Lipworth
Repeated Dosing Effects of Mediator Antagonists in Inhaled Corticosteroid-Treated Atopic Asthmatic Patients
Chest, April 1, 2004; 125(4): 1372 - 1377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 265 - 276.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society