help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on February 13, 2003, doi:10.1164/rccm.200209-1055OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 9, May 2003, 1181-1185

A more recent version of this article appeared on May 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200209-1055OCv1
167/9/1181    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Young, T.
Right arrow Articles by Peterson, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, T.
Right arrow Articles by Peterson, A.

Submitted on September 30, 2002
Accepted on January 26, 2003

Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study

Terry Young*, Laurel Finn, Diane Austin, and Andrea Peterson

* To whom correspondence should be addressed. E-mail: tbyoung{at}wisc.edu.

Menopause is widely considered to be a risk factor for sleep-disordered breathing, but this hypothesis has not been adequately tested. The association of pre-, peri, and postmenopause with sleep-disordered breathing was investigated with a population-based sample of 589 women enrolled in the Wisconsin Sleep Cohort Study. Menopausal status was determined from menstrual history, hysterectomy and oophorectomy, hormone replacement therapy, serum level of follicle stimulating hormone, and vasomotor symptoms. Sleep disordered breathing was indicated by the frequency of apnea and hypopnea events per hour of sleep, measured by in-laboratory polysomnography. Multivariable logistic regression was used to estimate odds ratios for having >=5 and >=15 apnea and hypopnea/hour. Odds ratios (95% confidence interval), adjusted for age, body habitus, smoking, and other potential confounding factors, for >= 5 apnea and hypopnea /hour were 1.2(0.7, 2.2) with perimenopause and 2.6 (1.4, 4.8) with postmenopause; odds ratios for >=15 apnea and hypopnea/hour were 1.1 (0.5, 2.2) with perimenopause and 3.5 (1.4, 8.8) with postmenopause. The menopausal transition is significantly associated with increased likelihood of having sleep-disordered breathing, independent of known confounding factors. Evaluation for sleep-disordered breathing should be a priority for menopausal women with complaints of snoring, daytime sleepiness or unsatisfactory sleep.
Key words: sleep apnea, obstructive sleep apnea, HRT, women, epidemiology




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
A. R. Schwartz, S. P. Patil, A. M. Laffan, V. Polotsky, H. Schneider, and P. L. Smith
Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Proceedings of the ATS, February 15, 2008; 5(2): 185 - 192.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
B. Buyse and the participants of working group 2
Treatment effects of sleep apnoea: where are we now?
Eur. Respir. Rev., December 1, 2007; 16(106): 146 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Katayama, C. A. Smith, K. S. Henderson, and J. A. Dempsey
Chronic intermittent hypoxia increases the CO2 reserve in sleeping dogs
J Appl Physiol, December 1, 2007; 103(6): 1942 - 1949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Parati, C. Lombardi, and K. Narkiewicz
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1671 - R1683.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Ahuja, J. H. Mateika, M. P. Diamond, and M. Safwan Badr
Ventilatory sensitivity to carbon dioxide before and after episodic hypoxia in women treated with testosterone
J Appl Physiol, May 1, 2007; 102(5): 1832 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. P. Patil, H. Schneider, J. J. Marx, E. Gladmon, A. R. Schwartz, and P. L. Smith
Neuromechanical control of upper airway patency during sleep
J Appl Physiol, February 1, 2007; 102(2): 547 - 556.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W. T. McNicholas, M. R. Bonsignore, and the Management Committee of EU COST ACTION B26
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
Eur. Respir. J., January 1, 2007; 29(1): 156 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Teramoto, H. Kume, Y. Yamaguchi, H. Yamamoto, Y. Hanaoka, M. Ishii, T. Ishii, and Y. Ouchi
Improvement of endothelial function with allopurinol may occur in selected patients with OSA: effect of age and sex
Eur. Respir. J., January 1, 2007; 29(1): 216 - 217.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
A. G. Zabka, G. S. Mitchell, and M. Behan
Conversion from testosterone to oestradiol is required to modulate respiratory long-term facilitation in male rats
J. Physiol., November 1, 2006; 576(3): 903 - 912.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Svensson, E. Lindberg, T. Naessen, and C. Janson
Risk factors associated with snoring in women with special emphasis on body mass index: a population-based study.
Chest, April 1, 2006; 129(4): 933 - 941.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Hedner, K. Bengtsson-Bostrom, Y. Peker, L. Grote, L. Rastam, and U. Lindblad
Hypertension prevalence in obstructive sleep apnoea and sex: a population-based case-control study.
Eur. Respir. J., March 1, 2006; 27(3): 564 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. I. Pack
Advances in Sleep-disordered Breathing
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 7 - 15.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Young, P. E. Peppard, and S. Taheri
Excess weight and sleep-disordered breathing
J Appl Physiol, October 1, 2005; 99(4): 1592 - 1599.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. I. Pack, T. Gislason, and H. Hakonarson
Linkage to Apnea-Hypopnea Index Across the Life-Span: Is this a Viable Strategy?
Am. J. Respir. Crit. Care Med., December 1, 2004; 170(11): 1260 - 1260.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. D. Doan, S. Gagnon, and V. Joseph
Prenatal blockade of estradiol synthesis impairs respiratory and metabolic responses to hypoxia in newborn and adult rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R612 - R618.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
T. Young, J. Skatrud, and P. E. Peppard
Risk Factors for Obstructive Sleep Apnea in Adults
JAMA, April 28, 2004; 291(16): 2013 - 2016.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Sleep-Disordered Breathing, Control of Breathing, Respiratory Muscles, Pulmonary Function Testing in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 254 - 264.
[Full Text] [PDF]

Home page
 HypertensionHome page
R. Wolk, A. S.M. Shamsuzzaman, and V. K. Somers
Obesity, Sleep Apnea, and Hypertension
Hypertension, December 1, 2003; 42(6): 1067 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. H. Sanders
The Upper Airway and Sleep-disordered Breathing: Getting the Big Picture
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 509 - 510.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. P. White
The Hormone Replacement Dilemma for the Pulmonologist
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1165 - 1166.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society