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Published ahead of print on April 2, 2003, doi:10.1164/rccm.200209-1028OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 12, June 2003, 1664-1669

A more recent version of this article appeared on June 15, 2003
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Submitted on September 24, 2002
Accepted on March 25, 2003

Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in COPD patients

Annabelle COUILLARD1*, Francois MALTAIS2, Didier SAEY2, Richard DEBIGARE2, Annie MICHAUD2, Christelle KOECHLIN1, Pierre LEBLANC2, and Christian PREFAUT1

1 Laboratory of Physiologie des interactions, Hopital Arnaud de Villeneuve, Montpellier cedex 5, France, 2 Centre de recherche en cardiologie et pneumologie, Hopital Laval, Ste Foy, Quebec, Canada

* To whom correspondence should be addressed. E-mail: annabelle_couillard{at}yahoo.fr.

Exercise-induced muscle oxidative stress may be involved in the myopathy associated with chronic obstructive pulmonary disease (COPD). This study was designed to look at whether local exercise induces muscle oxidative stress and whether this may be associated with the reduced muscle endurance in COPD. Quadriceps endurance was measured in 12 patients with COPD (FEV1 = 0.96 ± 0.14 SEM) and 10 healthy sedentary subjects by knee extensions of the dominant leg. Biopsies of the vastus lateralis were obtained before and 48 hours after exercise. Muscle oxidative stress was measured by lipid peroxidation (TBARs) and oxidized proteins. Muscle antioxidant was evaluated by peroxidase glutathion activity (GPX). Quadriceps endurance was significantly reduced in patients with COPD (p < 0.01). Forty-eight hours post-exercise, only COPD patients had a significant increase in muscle TBARs (p < 0.05) and oxidized proteins (p < 0.05) while increased GPX activity was only observed in controls (p < 0.05). Both increases in muscle TBARs and oxidized proteins were significantly and inversely correlated with quadriceps endurance in COPD (p < 0.05). Local exercise induced muscle oxidative stress in COPD patients while it failed to raise antioxidant activity. In these individuals, muscle oxidative stress was associated with reduced quadriceps endurance.
Key words: Malondialdehyde, Skeletal muscle, Glutathion peroxidase, Myopathy, COPD




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