help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on March 20, 2003, doi:10.1164/rccm.200207-782OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 11, June 2003, 1562-1566

A more recent version of this article appeared on June 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200207-782OCv1
167/11/1562    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spragg, R. G
Right arrow Articles by Marsh, J. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spragg, R. G
Right arrow Articles by Marsh, J. J

Submitted on July 31, 2002
Accepted on March 12, 2003

TREATMENT OF THE ACUTE RESPIRATORY DISTRESS SYNDROME WITH rSP-C SURFACTANT

Roger G Spragg1*, James F Lewis2, Wilhelm Wurst3, Dietrich Haefner3, Robert P Baughman4, Mark D Wewers5, and James J Marsh1

1 Medicine, University of California San Diego School of Medicine and San Diego Veterans Affairs Health Care System, San Diego, CA, USA, 2 Medicine, Lawson Health Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada, 3 ALTANA Pharma AG, Konstanz, Germany, 4 Medicine, University of Cincinnati, Cincinnati, Ohio, USA, 5 Medicine, Ohio State University, Columbus, Ohio, USA

* To whom correspondence should be addressed. E-mail: rspragg{at}ucsd.edu.

We performed a phase I/II trial in North America of a recombinant surfactant protein C based surfactant (Venticute®) as treatment for the acute respiratory distress syndrome. Patients were prospectively randomized to receive either standard therapy or standard therapy plus one of two doses of exogenous surfactant given four times over 24 hours. Surfactant administration was well tolerated. No significant treatment benefit was associated with surfactant treatment. Bronchoalveolar lavage of treated patients at 48 hours reflected the presence of exogenous surfactant components, did not show evidence of improved surface tension lowering function, and had interleukin-6 concentrations that were significantly lower than control group values, consistent with an anti-inflammatory treatment effect. The presence of exogenous surfactant was not detected in lavage fluid obtained at 120 hours. Future studies might rationally employ larger surfactant doses and a more prolonged dosing schedule.
Key words: Pulmonary surfactant, surfactant apoprotein C, phospholipids, interleukin 6




This article has been cited by other articles:


Home page
 ChestHome page
R. G. Spragg, F. J. H. Taut, A. Gunther, and G. Rippin
Response
Chest, July 1, 2009; 136(1): 321 - 322.
[Full Text] [PDF]

Home page
 ChestHome page
F. J. H. Taut, G. Rippin, P. Schenk, G. Findlay, W. Wurst, D. Hafner, J. F. Lewis, W. Seeger, A. Gunther, and R. G. Spragg
A Search for Subgroups of Patients With ARDS Who May Benefit From Surfactant Replacement Therapy: A Pooled Analysis of Five Studies With Recombinant Surfactant Protein-C Surfactant (Venticute)
Chest, October 1, 2008; 134(4): 724 - 732.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Yamashita, A. Forbes, J. M. Tessolini, L.-J. Yao, J. F. Lewis, and R. A. W. Veldhuizen
Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation
Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L724 - L732.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
K. M. Schuster, R. Alouidor, and E. S. Barquist
Nonventilatory Interventions in the Acute Respiratory Distress Syndrome
J Intensive Care Med, January 1, 2008; 23(1): 19 - 32.
[Abstract] [PDF]

Home page
 ChestHome page
M. Ikegami, E. A. Scoville, S. Grant, T. Korfhagen, W. Brondyk, R. K. Scheule, and J. A. Whitsett
Surfactant Protein-D and Surfactant Inhibit Endotoxin-Induced Pulmonary Inflammation
Chest, November 1, 2007; 132(5): 1447 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P. Markart, C. Ruppert, M. Wygrecka, T. Colaris, B. Dahal, D. Walmrath, H. Harbach, J. Wilhelm, W. Seeger, R. Schmidt, et al.
Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids
Thorax, July 1, 2007; 62(7): 588 - 594.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. S. Calfee and M. A. Matthay
Nonventilatory Treatments for Acute Lung Injury and ARDS
Chest, March 1, 2007; 131(3): 913 - 920.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
M. Cepkova and M. A. Matthay
Pharmacotherapy of Acute Lung Injury and the Acute Respiratory Distress Syndrome
J Intensive Care Med, May 1, 2006; 21(3): 119 - 143.
[Abstract] [PDF]

Home page
 Mayo Clin Proc.Home page
R. Jain and A. DalNogare
Pharmacological Therapy for Acute Respiratory Distress Syndrome
Mayo Clin. Proc., February 1, 2006; 81(2): 205 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. R. Bernard
Acute Respiratory Distress Syndrome: A Historical Perspective
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 798 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
B. S. Burleson and E. D. Maki
Acute Respiratory Distress Syndrome
Journal of Pharmacy Practice, April 1, 2005; 18(2): 118 - 131.
[Abstract] [PDF]

Home page
 NEJMHome page
R. G. Spragg, J. F. Lewis, H.-D. Walmrath, J. Johannigman, G. Bellingan, P.-F. Laterre, M. C. Witte, G. A. Richards, G. Rippin, F. Rathgeb, et al.
Effect of Recombinant Surfactant Protein C-Based Surfactant on the Acute Respiratory Distress Syndrome
N. Engl. J. Med., August 26, 2004; 351(9): 884 - 892.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Anderson, R. C. Molthen, C. A. Dawson, S. T. Haworth, J. L. Bull, M. R. Glucksberg, and J. B. Grotberg
Effect of ventilation rate on instilled surfactant distribution in the pulmonary airways of rats
J Appl Physiol, July 1, 2004; 97(1): 45 - 56.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
P. Prodhan and N. Noviski
Pediatric Acute Hypoxemic Respiratory Failure: Management of Oxygenation
J Intensive Care Med, May 1, 2004; 19(3): 140 - 153.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Critical Care Medicine in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 239 - 253.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 277 - 287.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Johansson, M. Some, B.-M. Linderholm, A. Almlen, T. Curstedt, and B. Robertson
A synthetic surfactant based on a poly-Leu SP-C analog and phospholipids: effects on tidal volumes and lung gas volumes in ventilated immature newborn rabbits
J Appl Physiol, November 1, 2003; 95(5): 2055 - 2063.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  ATS Quiz on Sleep Study Tracings