Published ahead of print on November 14, 2002, doi:10.1164/rccm.200207-728OC
Am. J. Respir. Crit. Care Med., Volume 167, Number 4, February 2003, 587-592
A more recent version of this article appeared on February 15, 2003
Submitted on July 22, 2002
Accepted on October 22, 2002
Adaptive Immunity to Nontypeable Haemophilus influenzae
Paul T King1*, Paul E Hutchinson2, Paul D Johnson3, Peter W Holmes4, Nicholas J Freezer4, and Stephen R Holdsworth2
1 Department of Respiratory Medicine, Monash Medical Centre, Melbourne, Victoria, Australia; Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia,
2 Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia,
3 Department of Infectious Disease, Austin and Repatriation Medical Centre, Melbourne, Victoria, Australia,
4 Department of Respiratory Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
* To whom correspondence should be addressed. E-mail: ptking{at}netspace.net.au.
Nontypeable Haemophilus influenzae (NTHi) colonizes the upper respiratory tract of most healthy people and is also a major cause of infection in chronic obstructive lung disease. The immune response to this bacterium has not been well characterized. We tested the hypothesis that recurrent airway infection with NTHi may be associated with non-clearing adaptive immunity. Study subjects were healthy controls and patients with idiopathic bronchiectasis who had severe chronic infection with Haemophilus influenzae. We established that all subjects in both groups had detectable antibody to NTHi, suggesting that most normal people have developed an adaptive immune response. To characterize the nature of the immune response we measured antigen specific production of T helper cell cytokines and CD40 ligand by flow cytometry and immunoglobulin subclass levels in peripheral blood. We found that normal control subjects made a type 1 T helper cell response to NTHi with distinct CD40 ligand production. In contrast subjects with bronchiectasis had predominant production of type 2 T helper cell cytokines, decreased expression of CD40 ligand and different immunoglobulin-G subclass production. Therefore chronic infection with NTHi in bronchiectasis is associated with a change in adaptive immunity which may be important in the pathogenesis of bronchial infection.
Key words: haemophilus influenzae, bronchiectasis, lymphocyte, immunoglobulin
This article has been cited by other articles:
|
|
|
|
 
S. J. Moghaddam, H. Li, S.-N. Cho, M. K. Dishop, I. I. Wistuba, L. Ji, J. M. Kurie, B. F. Dickey, and F. J. DeMayo
Promotion of Lung Carcinogenesis by Chronic Obstructive Pulmonary Disease-Like Airway Inflammation in a K-ras-Induced Mouse Model
Am. J. Respir. Cell Mol. Biol.,
April 1, 2009;
40(4):
443 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Zhu, A. S. Gadgil, R. Givelber, M. P. George, M. W. Stoner, F. C. Sciurba, and S. R. Duncan
Peripheral T Cell Functions Correlate with the Severity of Chronic Obstructive Pulmonary Disease
J. Immunol.,
March 1, 2009;
182(5):
3270 - 3277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Pang, D. Winn, R. Johnson, W. Hong, S. West-Barnette, N. Kock, and W. E. Swords
Lipooligosaccharides Containing Phosphorylcholine Delay Pulmonary Clearance of Nontypeable Haemophilus influenzae
Infect. Immun.,
May 1, 2008;
76(5):
2037 - 2043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fuschillo, A. De Felice, and G. Balzano
Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms
Eur. Respir. J.,
February 1, 2008;
31(2):
396 - 406.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Roghanian, E. M. Drost, W. MacNee, S. E. M. Howie, and J.-M. Sallenave
Inflammatory Lung Secretions Inhibit Dendritic Cell Maturation and Function via Neutrophil Elastase
Am. J. Respir. Crit. Care Med.,
December 1, 2006;
174(11):
1189 - 1198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Boyton, J. Smith, R. Ward, M. Jones, L. Ozerovitch, R. Wilson, M. Rose, J. Trowsdale, and D. M. Altmann
HLA-C and Killer Cell Immunoglobulin-like Receptor Genes in Idiopathic Bronchiectasis
Am. J. Respir. Crit. Care Med.,
February 1, 2006;
173(3):
327 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rosell, E. Monso, N. Soler, F. Torres, J. Angrill, G. Riise, R. Zalacain, J. Morera, and A. Torres
Microbiologic Determinants of Exacerbation in Chronic Obstructive Pulmonary Disease
Arch Intern Med,
April 25, 2005;
165(8):
891 - 897.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Tobin
Tuberculosis, Lung Infections, Interstitial Lung Disease, Social Issues and Journalology in AJRCCM 2003
Am. J. Respir. Crit. Care Med.,
January 15, 2004;
169(2):
288 - 300.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. F. Murphy
Immunity to Nontypeable Haemophilus influenzae: Elucidating Protective Responses
Am. J. Respir. Crit. Care Med.,
February 15, 2003;
167(4):
486 - 487.
[Full Text]
[PDF]
|
|
|
Copyright © 2002 American Thoracic Society
|
|
|
