Published ahead of print on February 25, 2003, doi:10.1164/rccm.200207-674OC
Am. J. Respir. Crit. Care Med., Volume 167, Number 10, May 2003, 1321-1328
A more recent version of this article appeared on May 15, 2003
Submitted on July 9, 2002
Accepted on February 23, 2003
Parenteral nutrition with fish oil modulates cytokine response in septic patients
Konstantin Mayer1*, Stephanie Gokorsch1, Christine Fegbeutel1, Katja Hattar1, Simone Rosseau2, Dieter Walmrath1, Werner Seeger1, and Friedrich Grimminger1
1 Internal Medicine, Justus Liebig University, Giessen, Germany,
2 Internal Medicine, Charite, Humboldt University, Berlin, Germany
* To whom correspondence should be addressed. E-mail: Konstantin.Mayer{at}innere.med.uni-giessen.de.
Infusion of fish oil-based (n-3) lipids may influence leukocyte function and plasma lipids in critical care patients. Twenty-one septic patients requiring parenteral nutrition were randomized to receive a n-3 lipid emulsion rich in eicosapentaenoic acid and docosahexaenoic acid or a conventional (n-6)lipid emulsion (index fatty acid: arachidonic acid) for five days. The impact on plasma free fatty acids, mononuclear leukocyte cytokine generation, and membrane fatty acid composition was examined. Cytokine synthesis by isolated mononuclear leukocyte was elicited by endotoxin. Before onset of lipid infusion therapy, plasma free fatty acid concentrations were greatly increased in septic patients, with arachidonic acid by far surpassing eicosapentaenoic acid and docosahexaenoic acid, a feature maintained during conventional lipid infusion. Within two days of fish oil infusion, free n-3 fatty acids increased, and the n-3/n-6 ratio was reversed, with rapid incorporation of n-3 fatty acids into mononuclear leukocyte membranes. Generation of pro-inflammatory cytokines by mononuclear leukocytes was markedly amplified during n-6 and suppressed during n-3 lipid application. After
termination of lipid administration, free n-3 fatty acid concentrations and mononuclear leukocyte cytokine synthesis returned to pre-infusion values. Use of lipid infusions might allow to combine intravenous alimentation with differential impact on inflammatory events and immunological
functions in septic patients.
Key words: monocyte, eicosapentaenoic acid, arachidonic acid, mononuclear leukocyte
This article has been cited by other articles:
|
|
|
|
 
F. Gottrand
Long-Chain Polyunsaturated Fatty Acids Influence the Immune System of Infants
J. Nutr.,
September 1, 2008;
138(9):
1807S - 1812S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gawecka, J. Michalkiewicz, M. K. Kornacka, B. Luckiewicz, and I. Kubiszewska
Immunologic Properties Differ in Preterm Infants Fed Olive Oil vs Soy-Based Lipid Emulsions During Parenteral Nutrition
JPEN J Parenter Enteral Nutr,
July 1, 2008;
32(4):
448 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Wanten and P. C Calder
Immune modulation by parenteral lipid emulsions
Am. J. Clinical Nutrition,
May 1, 2007;
85(5):
1171 - 1184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Senkal, B. Geier, M. Hannemann, T. Deska, J. Linseisen, G. Wolfram, and M. Adolph
Supplementation of {Omega}-3 Fatty Acids in Parenteral Nutrition Beneficially Alters Phospholipid Fatty Acid Pattern
JPEN J Parenter Enteral Nutr,
January 1, 2007;
31(1):
12 - 17.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. L. Jensen
Inflammation as the Key Interface of the Medical and Nutrition Universes: A Provocative Examination of the Future of Clinical Nutrition and Medicine
JPEN J Parenter Enteral Nutr,
September 1, 2006;
30(5):
453 - 463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Waitzberg, R. S. Torrinhas, and T. M. Jacintho
New Parenteral Lipid Emulsions for Clinical Use
JPEN J Parenter Enteral Nutr,
July 1, 2006;
30(4):
351 - 367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Cury-Boaventura, R. Gorjao, T. M. de Lima, T. M. Piva, C. M. Peres, F. G. Soriano, and R. Curi
Toxicity of a Soybean Oil Emulsion on Human Lymphocytes and Neutrophils
JPEN J Parenter Enteral Nutr,
March 1, 2006;
30(2):
115 - 123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Compher, C. Spencer, and B. P. Kinosian
Perioperative Parenteral Nutrition: Impact on Morbidity and Mortality in Surgical Patients
Nutr Clin Pract,
August 1, 2005;
20(4):
460 - 467.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Senkal, R. Haaker, J. Linseisen, G. Wolfram, H.-H. Homann, and P. Stehle
Preoperative Oral Supplementation with Long-Chain {Omega}-3 Fatty Acids Beneficially Alters Phospholipid Fatty Acid Patterns in Liver, Gut Mucosa, and Tumor Tissue
JPEN J Parenter Enteral Nutr,
July 1, 2005;
29(4):
236 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Aiko, Y. Yoshizumi, S. Tsuwano, M. Shimanouchi, Y. Sugiura, and T. Maehara
The Effects of Immediate Enteral Feeding with a Formula Containing High Levels of {omega}-3 Fatty Acids in Patients After Surgery for Esophageal Cancer
JPEN J Parenter Enteral Nutr,
May 1, 2005;
29(3):
141 - 147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Vadasz, R. E. Morty, M. G. Kohstall, A. Olschewski, F. Grimminger, W. Seeger, and H. A. Ghofrani
Oleic Acid Inhibits Alveolar Fluid Reabsorption: A Role in Acute Respiratory Distress Syndrome?
Am. J. Respir. Crit. Care Med.,
March 1, 2005;
171(5):
469 - 479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Mizock and S. J. DeMichele
The Acute Respiratory Distress Syndrome: Role of Nutritional Modulation of Inflammation Through Dietary Lipids
Nutr Clin Pract,
December 1, 2004;
19(6):
563 - 574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Tobin
Critical Care Medicine in AJRCCM 2003
Am. J. Respir. Crit. Care Med.,
January 15, 2004;
169(2):
239 - 253.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Mayer, S. Meyer, M. Reinholz-Muhly, U. Maus, M. Merfels, J. Lohmeyer, F. Grimminger, and W. Seeger
Short-Time Infusion of Fish Oil-Based Lipid Emulsions, Approved for Parenteral Nutrition, Reduces Monocyte Proinflammatory Cytokine Generation and Adhesive Interaction with Endothelium in Humans
J. Immunol.,
November 1, 2003;
171(9):
4837 - 4843.
[Abstract]
[Full Text]
[PDF]
|
|
|
Copyright © 2003 American Thoracic Society
|
|
|
