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Published ahead of print on February 20, 2003, doi:10.1164/rccm.200207-665OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 12, June 2003, 1704-1710

A more recent version of this article appeared on June 15, 2003
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Submitted on July 30, 2002
Accepted on February 18, 2003

Altered Clearance of Gadolinium-DTPA Aerosol from Bleomycin-Injured Dog Lungs: Initial Observations

Kazuyoshi Suga1*, Yue Yuan1, Nobuhiko Ogasawara1, Toshinobu Tsukuda1, and Naofumi Matsunaga1

1 Radiology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan

* To whom correspondence should be addressed. E-mail: sugar{at}po.cc.yamaguchi-u.ac.jp.

To characterize altered alveolar transfer to solute in bleomycin (BLM)-injured lungs, 8 dogs underwent a Gd-DTPA aerosol (Gd-AS) MRI study before and on Day 7 and 40 after tracheal instillation of BLM (0.75 mg) in the left lungs. Consecutive fast-gradient-echo MRI was acquired during and after spontaneous inhalation of 200 mmol/L Gd-AS. The slope (Kep) and clearance half-time (T1/2) of logarithmic regression lines for clearance curves were estimated. Histology on Day 40 was compared with that on Day 7 in other 3 dogs. On Day 7 and 40, Gd-AS deposition was heterogeneously reduced in the affected lungs. On Day 7 with multifocal intraalveolar exudative changes, Kep in affected areas was significantly increased compared with baseline (2.5 x 10 -3 min -1 ±0.3 vs. 1.7 x 10 -3 min -1 ±0.2; P <0.0001), with significant decrease in T1/2 (121.6 min ±19.7 vs. 170.4 min ±15.8; P <0.001). However, on Day 40 with multifocal interstitial fibrosis, Kep and T1/2 were recovered toward baseline. BLM-injured lungs can be characterized by accelerated Gd-AS clearance during the acute exudative phase and their recovery during the chronic fibrotic phase. This technique is acceptable for monitoring alveolar transfer changes in BLM-injured lungs.
Key words: Magnetic resonance (MR) imaging, Aerosol, Bleomycin-injured lungs, Gadolinium diethylenetriaminepentaacetic acid,




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