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Published ahead of print on December 18, 2002, doi:10.1164/rccm.200206-542OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 5, March 2003, 690-694

A more recent version of this article appeared on March 1, 2003
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Submitted on June 18, 2002
Accepted on December 6, 2002

Pulmonary Function and Health Related Quality of Life in Survivors of ARDS

James Orme Jr.1*, Joshua S Romney2, Ramona O Hopkins3, Donna Pope2, Karen J Chan4, George Thomsen2, Robert O Crapo2, and Lindell K Weaver1

1 Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah, USA; Department of Medicine, Pulmonary and Critical Care Divisions, University of Utah, Salt Lake City, Utah, USA, 2 Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah, USA, 3 Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah, USA; Psychology Department and Neuroscience Center, Brigham Young University, Provo, Utah, USA, 4 Statistical Data Center, LDS Hospital, Salt Lake City, Utah, USA

* To whom correspondence should be addressed. E-mail: ldjorme{at}ihc.com.

While survival rates for Acute Respiratory Distress Syndrome have increased, there is only limited information regarding the quality of life and the relationship between quality of life and pulmonary function after survival. We prospectively measured pulmonary function, emotional function and health-related quality of life in a cohort of Acute Respiratory Distress Syndrome survivors recruited from patients who were enrolled in a randomized clinical trial of high versus low tidal volume mechanical ventilation, one year after their recovery. No significant differences were found between the patients treated with high and low tidal volumes on any pulmonary function measure. Approximately 80% of the patients in both groups demonstrated reduced diffusing capacity and 20% had airflow obstruction and 20% had chest restriction. Scores on measures of depression and anxiety were within the normal ranges, suggesting they did not have significant affective symptoms. However, both groups reported decreased health-related quality of life in physical function on the Medical Outcome Study Short Form Health Survey and Sickness Impact Profile questionnaire. The pulmonary function abnormalities correlated with decreased health related quality of life for domains reflecting physical function. Acute Respiratory Distress Syndrome survivors treated with high and low tidal volumes have abnormal pulmonary function that was related to decreased health-related quality of life one year following hospital discharge.
Key words: Acute Respiratory Distress Syndrome, ARDS, pulmonary function, quality of life




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