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Published ahead of print on October 31, 2002, doi:10.1164/rccm.200206-507OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 3, February 2003, 395-399

A more recent version of this article appeared on February 1, 2003
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Submitted on June 4, 2002
Accepted on October 14, 2002

Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation

Massimo Corradi1*, Giuseppina Folesani1, Roberta Andreoli1, Paola Manini1, Alessandro Bodini2, Giorgio Piacentin2, Silvia Carraro3, Stefania Zanconato3, and Eugenio Baraldi3

1 Department of Clinical Medicine, Nephrology and Health Sciences, Research Center I.S.P.E.S.L., University of Parma, Parma, Italy, 2 Department of Pediatrics, University of Verona, Verona, Italy, 3 Department of Pediatrics, University of Padova, Padova, Italy

* To whom correspondence should be addressed. E-mail: corradi{at}nemo.unipr.it.

Oxidative stress is implicated in the pathogenesis of asthma and clinical studies show an imbalance in the level of oxidants to the level of antioxidants in asthmatics. Aldehydes and glutathione are examples of biomarkers of oxidant-induced damage and antioxidant status in asthma, respectively. In the study, we applied analytical techniques based on liquid chromatography for the assessment of aldehydes and glutathione in the exhaled breath condensate of asthmatic children and in nonasthmatic controls. Twelve asthmatics were evaluated at exacerbation and after five days of therapy with prednisone. At exacerbation, malondialdehyde levels were higher in asthmatics (30.2 ± 2.4 nM) than in controls (19.4 ± 1.9 nM, p=0.002) and were reduced after steroid therapy (18.5 ± 1.6 nM, p=0.001). At exacerbation, glutathione levels were lower in asthmatics (5.96 ± 0.6 nM) than in controls (14.1 ± 0.8 nM, p<0.0001) and increased after the therapy (8.44 ± 1. 2 nM, p=0.04). Malondialdehyde and glutathione both in asthmatics and controls were negatively correlated (r= -0.5, p=0.001). The study shows that aldehydes and glutathione are detectable in the exhaled breath condensate of asthmatic and healthy children and that their levels are modified during asthma exacerbation and after a 5-day course of therapy with oral prednisone.
Key words: Oxidative stress, Exhaled Breath Condensate, Asthma, Children




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