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Published ahead of print on August 1, 2002, doi:10.1164/rccm.200205-421OC

Am. J. Respir. Crit. Care Med., Volume 166, Number 8, October 2002, 1099-1104

A more recent version of this article appeared on October 15, 2002
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Submitted on May 29, 2002
Accepted on July 25, 2002

PULMONARY FUNCTION TESTS IN PRESCHOOL CHILDREN WITH CYSTIC FIBROSIS

NICOLE BEYDON1*, FRANCIS AMSALLEM2, MIREILLE BELLET3, MICHELE BOULE4, MICHELE CHAUSSAIN5, ANDRE DENJEAN6, REGIS MATRAN7, ISABELLE PIN8, CORINNE ALBERTI9, and CLAUDE GAULTIER1

1 physiology, Robert Debre Hospital, Paris, France, 2 pediatric, Arnaud de Villeneuve Hospital, Montpellier, France, 3 physiology, Morvan Hospital, Brest, France, 4 physiology, Trousseau, Paris, France, 5 physiology, Saint Vincent de Paul hospital, Paris, France, 6 physiology, Poitiers Hospital, Poitiers, France, 7 physiology, Calmette Hospital, Lille, France, 8 physiology, Grenoble Hospital, Grenoble, France, 9 public health, Robert Debre Hospital, Paris, France

* To whom correspondence should be addressed. E-mail: nicole.beydon{at}rdb.ap-hop-paris.fr.

Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis. The objective of this multicenter study was to compare pulmonary function in 39 preschool children with cystic fibrosis (height, 90 to 130 cm; 16 homozygous {Delta}F508) and in 79 healthy controls. Functional residual capacity (helium dilution technique) and expiratory interrupter resistance (interrupter technique) were measured. As compared to controls, cystic fibrosis patients had significantly higher expiratory interrupter resistance expressed as absolute values and as Z-scores (1.05±0.36 vs. 0.80±0.20 KPa.L-1.s, P<0.0001; and 1.31±1.72 vs. 0.19±0.97, P<0.0001) and significantly lower specific expiratory interrupter conductance (1.29±0.34 vs. 1.63±0.43 kPa-1.s-1, P<0.0001). The effect of the bronchodilator salbutamol on expiratory interrupter resistance was not significantly different between cystic fibrosis and control children. Expiratory interrupter resistance Z-scores were significantly higher in cystic fibrosis children exposed to passive smoke (n=8) (P<0.03). Cystic fibrosis children with a history of respiratory symptoms (n=31) had significantly higher functional residual capacity Z-scores (P<0.02) and lower specific expiratory interrupter conductance Z-scores (P<0.04). Genotype did not influence the data. We conclude that expiratory interrupter resistance and functional residual capacity measurements may help to follow-up young cystic fibrosis children unable to perform reproducible forced expiratory maneuvers.
Key words: functional residual capacity, expiratory interrupter resistance, bronchodilator, genotype, passive smoke




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