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Published ahead of print on January 24, 2003, doi:10.1164/rccm.200205-409OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 8, April 2003, 1117-1123

A more recent version of this article appeared on April 15, 2003
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Submitted on May 10, 2002
Accepted on January 22, 2003

Contribution of Respiratory Disease to Non-Respiratory Mortality Associations with Air Pollution

Samantha F De Leon1*, George D Thurston1, and Kazuhiko Ito1

1 Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA

* To whom correspondence should be addressed. E-mail: deleon{at}env.med.nyu.edu.

Many time-series studies have found that individuals with primary cardiac conditions were susceptible to the adverse effects associated with increased ambient particle levels. However, the mechanism(s) of these associations are not yet understood. In this study, we evaluate whether individuals with non-respiratory primary causes of death that also had contributing respiratory causes listed on their death certificates were more affected by air pollution, as compared to those not having contributing respiratory conditions. Short-term associations between ambient particulate matter (<= 10 micrometers in aerodynamic diameter) and mortality were modeled in New York City for the years 1985-1994. It was observed that among those >= 75 years, those with contributing respiratory disease had higher relative risks [95% confidence intervals] calculated per inter-quartile range, as compared to those without contributing respiratory disease, for both circulatory deaths (relative risk = 1.066 [1.027-1.106], versus 1.022 [1.008-1.035]), and cancer deaths (relative risk = 1.129 [1.041-1.225], versus 1.025 [1.000-1.050]). However, this pattern of association was not observed for those <75 years. The results of this study suggest that past studies may have under-estimated the role of respiratory disease in pollution-mortality associations, especially among older adults.


Key words: Particulate matter, and circulatory mortality




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