help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on September 17, 2002, doi:10.1164/rccm.200204-298OC

Am. J. Respir. Crit. Care Med., Volume 167, Number 1, January 2003, 24-31

A more recent version of this article appeared on January 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200204-298OCv1
167/1/24    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Culpitt, S. V
Right arrow Articles by Barnes, P. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Culpitt, S. V
Right arrow Articles by Barnes, P. J

Submitted on April 8, 2002
Accepted on September 12, 2002

Impaired Inhibition by Dexamethasone of Cytokine Release by Alveolar Macrophages from COPD Patients

Sarah V Culpitt1, Duncan F Rogers1, Pallav Shah1, Carmen De Matos1, Richard E Russell1, Louise E Donnelly1*, and Peter J Barnes1

1 Thoracic Medicine, National Heart & Lung Institute, London, United Kingdom

* To whom correspondence should be addressed. E-mail: l.donnelly{at}ic.ac.uk.

Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the respiratory tract in which macrophages are the predominant inflammatory cell and for which the efficacy of treatment with corticosteroids is controversial. We investigated the effect of dexamethasone on basal and interleukin (IL)-1ß or cigarette smoke media (CSM) stimulated release of IL-8 and granulocyte macrophage-colony stimulating factor (GM-CSF) by bronchoalveolar lavage macrophages from cigarette smokers and patients with COPD (n=15). Basal release of IL-8 was ~5-fold greater in COPD patients than smokers, whereas GM-CSF was similar for each group. IL-1ß and CSM increased IL-8 and GM-CSF release by macrophages from both smokers and COPD patients. Dexamethasone did not inhibit basal or stimulated IL-8 release from macrophages from COPD patients, but inhibited release in smokers. In contrast, basal and IL-1ß stimulated GM-CSF release, but not CSM stimulated release, was inhibited by dexamethasone. We conclude that the lack of efficacy of corticosteroids in COPD might be due to the relative steroid insensitivity of macrophages in the respiratory tract.
Key words: corticosteroid; cigarette smoke; chronic obstructive pulmonary disease




This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Letuve, A. Kozhich, N. Arouche, M. Grandsaigne, J. Reed, M.-C. Dombret, P. A. Kiener, M. Aubier, A. J. Coyle, and M. Pretolani
YKL-40 Is Elevated in Patients with Chronic Obstructive Pulmonary Disease and Activates Alveolar Macrophages
J. Immunol., October 1, 2008; 181(7): 5167 - 5173.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. K. Meja, S. Rajendrasozhan, D. Adenuga, S. K. Biswas, I. K. Sundar, G. Spooner, J. A. Marwick, P. Chakravarty, D. Fletcher, P. Whittaker, et al.
Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2
Am. J. Respir. Cell Mol. Biol., September 1, 2008; 39(3): 312 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. F. Chung and I. M. Adcock
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. A. Falk, O. A. Minai, and Z. Mosenifar
Inhaled and Systemic Corticosteroids in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, May 1, 2008; 5(4): 506 - 512.
[Abstract] [Full Text] [PDF]

Home page
 Therapeutic Advances in Respiratory DiseaseHome page
G. Braganza, R. Chaudhuri, and N. C. Thomson
Review: Treating patients with respiratory disease who smoke
Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 95 - 107.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Medicherla, M. F. Fitzgerald, D. Spicer, P. Woodman, J. Y. Ma, A. M. Kapoun, S. Chakravarty, S. Dugar, A. A. Protter, and L. S. Higgins
p38{alpha}-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation
J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 921 - 929.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Facchinetti, F. Amadei, P. Geppetti, F. Tarantini, C. Di Serio, A. Dragotto, P. M. Gigli, S. Catinella, M. Civelli, and R. Patacchini
{alpha},beta-Unsaturated Aldehydes in Cigarette Smoke Release Inflammatory Mediators from Human Macrophages
Am. J. Respir. Cell Mol. Biol., November 1, 2007; 37(5): 617 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Against the dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases.
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 240 - 243.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes, B. Chowdhury, S. A. Kharitonov, H. Magnussen, C. P. Page, D. Postma, and M. Saetta
Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 6 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L.-b. Li, D. Y. M. Leung, C. F. Hall, and E. Goleva
Divergent expression and function of glucocorticoid receptor {beta} in human monocytes and T cells
J. Leukoc. Biol., April 1, 2006; 79(4): 818 - 827.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes
Corticosteroid effects on cell signalling
Eur. Respir. J., February 1, 2006; 27(2): 413 - 426.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
K. Ito, S. Yamamura, S. Essilfie-Quaye, B. Cosio, M. Ito, P. J. Barnes, and I. M. Adcock
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-{kappa}B suppression
J. Exp. Med., January 23, 2006; 203(1): 7 - 13.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
I. M. Adcock and K. Ito
Glucocorticoid Pathways in Chronic Obstructive Pulmonary Disease Therapy
Proceedings of the ATS, November 1, 2005; 2(4): 313 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. J. Barnes
Theophylline in Chronic Obstructive Pulmonary Disease: New Horizons
Proceedings of the ATS, November 1, 2005; 2(4): 334 - 339.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Farkas, M.-C. Hahn, M. Schmoczer, N. Jentsch, K. Kratzel, M. Pfeifer, and C. Schulz
Expression of CXC Chemokine Receptors 1 and 2 in Human Bronchial Epithelial Cells
Chest, November 1, 2005; 128(5): 3724 - 3734.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. J. Walters, M. J. Paul-Clark, S. K. McMaster, K. Ito, I. M. Adcock, and J. A. Mitchell
Cigarette Smoke Activates Human Monocytes by an Oxidant-AP-1 Signaling Pathway: Implications for Steroid Resistance
Mol. Pharmacol., November 1, 2005; 68(5): 1343 - 1353.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
P. J. Barnes
New approaches to COPD
Eur. Respir. Rev., September 1, 2005; 14(94): 2 - 11.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. R. Pons, J. Sauleda, A. Noguera, J. Pons, B. Barcelo, A. Fuster, and A. G. N. Agusti
Decreased macrophage release of TGF-{beta} and TIMP-1 in chronic obstructive pulmonary disease
Eur. Respir. J., July 1, 2005; 26(1): 60 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Birrell, S. Wong, D. J. Hele, K. McCluskie, E. Hardaker, and M. G. Belvisi
Steroid-resistant Inflammation in a Rat Model of Chronic Obstructive Pulmonary Disease Is Associated with a Lack of Nuclear Factor-{kappa}B Pathway Activation
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 74 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes and R. A. Stockley
COPD: current therapeutic interventions and future approaches
Eur. Respir. J., June 1, 2005; 25(6): 1084 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. R. Pons, A. Noguera, D. Blanquer, J. Sauleda, J. Pons, and A. G. N. Agusti
Phenotypic characterisation of alveolar macrophages and peripheral blood monocytes in COPD
Eur. Respir. J., April 1, 2005; 25(4): 647 - 652.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes, I. M. Adcock, and K. Ito
Histone acetylation and deacetylation: importance in inflammatory lung diseases
Eur. Respir. J., March 1, 2005; 25(3): 552 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Balloy, M. Huerre, J.-P. Latge, and M. Chignard
Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis
Infect. Immun., January 1, 2005; 73(1): 494 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Barnes
Mediators of Chronic Obstructive Pulmonary Disease
Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. G. Belvisi
Regulation of Inflammatory Cell Function by Corticosteroids
Proceedings of the ATS, November 1, 2004; 1(3): 207 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
I. M. Adcock, K. Ito, and P. J. Barnes
Glucocorticoids: Effects on Gene Transcription
Proceedings of the ATS, November 1, 2004; 1(3): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. J. Barnes
Corticosteroid Resistance in Airway Disease
Proceedings of the ATS, November 1, 2004; 1(3): 264 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. E. Donnelly, R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. F. Leung, K. Ito, R. E. K. Russell, and P. J. Barnes
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms
Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L774 - L783.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
B. G. Cosio, L. Tsaprouni, K. Ito, E. Jazrawi, I. M. Adcock, and P. J. Barnes
Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages
J. Exp. Med., September 7, 2004; 200(5): 689 - 695.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.N.R. Dekhuijzen
Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease
Eur. Respir. J., April 1, 2004; 23(4): 629 - 636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 301 - 313.
[Full Text] [PDF]

Home page
 ThoraxHome page
S V Culpitt, D F Rogers, P S Fenwick, P Shah, C De Matos, R E K Russell, P J Barnes, and L E Donnelly
Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD
Thorax, November 1, 2003; 58(11): 942 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J. Barnes, S.D. Shapiro, and R.A. Pauwels
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
Eur. Respir. J., October 1, 2003; 22(4): 672 - 688.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
P. J. Barnes and I. M. Adcock
How Do Corticosteroids Work in Asthma?
Ann Intern Med, September 2, 2003; 139(5_Part_1): 359 - 370.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2002 American Thoracic Society 		  ATS PAR News