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Published ahead of print on September 5, 2002, doi:10.1164/rccm.200203-233OC

Am. J. Respir. Crit. Care Med., Volume 166, Number 10, November 2002, 1345-1349

A more recent version of this article appeared on November 15, 2002
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Submitted on March 21, 2002
Accepted on September 4, 2002

INCREASED LEUKOTRIENES IN EXHALED BREATH CONDENSATE IN CHILDHOOD ASTHMA

Zsuzsanna Csoma1*, Sergei A Kharitonov1, Beatrix Balint1, Andrew Bush2, Nicola M Wilson2, and Peter J Barnes1

1 Department of Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom, 2 Department of Pediatric Respiratory Care, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom

* To whom correspondence should be addressed. E-mail: csomalouk{at}hotmail.com.

Cysteinyl leukotrienes (cys-LTs: LTC4D4E4) are generated predominantly by mast cells and eosinophils, induce airway smooth muscle contraction, microvascular leakage and mucus hypersecretion whereas LTB4 is a potent chemoattractant of neutrophils. We measured cys-LTs and LTB4 in exhaled breath condensate in children aged 7-14 year including healthy nonatopic children (n=11) and children with mild intermittent (steroid naive n=11), mild persistent (low dose inhaled steroid treatment n=13), moderate to severe persistent asthma (high dose inhaled steroid treatment n=13). Exhaled LTB4 levels were increased in patients with mild and moderate to severe persistent asthma compared to mild intermittent asthmatic (126.0 ± 8.8 and 131.9 ± 7.1 vs. 52.7 ± 3.8 pg/ml P < 0.001 and P < 0.0001) and normal subjects (126.0 ± 8.8 and 131.9 ± 7.1 vs. 47.9 ± 4.1 pg/ml P < 0.0001). Elevated exhaled cys-LTs levels were found in mild and moderate to severe persistent asthma compared to normal subjects (27.9 ± 2.8 and 31.5 ± 4.5 vs. 18.5 ± 0.5 pg/ml P < 0.01 and P < 0.05). There was an inverse correlation between exhaled cys-LT and LTB4 in patients with mild persistent asthma. We conclude that exhaled cys-LTs and LTB4 may be non-invasive markers of airway inflammation in pediatric asthma.
Key words: leukotriene B4, cysteinyl-leukotrienes, exhaled breath condensate, asthma, children




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