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Published ahead of print on December 9, 2005, doi:10.1164/rccm.200508-1243PP
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American Journal of Respiratory and Critical Care Medicine Vol 173. pp. 483-490, (2006)
© 2006 American Thoracic Society
doi: 10.1164/rccm.200508-1243PP

Pulmonary Perspective

The Inflammatory Role of Platelets in Cystic Fibrosis

Brian P. O'Sullivan and Alan D. Michelson

Department of Pediatrics, UMass Memorial Health Care; Department of Pediatrics; and Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, Massachusetts

Correspondence and requests for reprints should be addressed to Brian P. O'Sullivan, M.D., Department of Pediatrics, UMass Memorial Health Care, 55 Lake Avenue, North Worcester, MA 01655. E-mail: osullivb{at}ummhc.org

ABSTRACT

Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocytes into inflamed tissue. We review the role of platelets in inflammation, how they assist in the recruitment of leukocytes into lung tissue in asthma, and evidence of their dysfunction in cystic fibrosis (CF). Platelet dysfunction in CF could contribute to pulmonary inflammation and tissue destruction. We hypothesize that platelet activation is important in CF lung disease and suggest research avenues that might help elucidate the role of activated platelets in CF.

Key Words: platelets • cystic fibrosis • inflammation • arachidonic acid • aspirin




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