Published ahead of print on June 23, 2005, doi:10.1164/rccm.200410-1335OC
© 2005 American Thoracic Society doi: 10.1164/rccm.200410-1335OC
Disease-specific Reference Equations for Lung Function in Patients with Cystic FibrosisDepartment of Probability and Statistics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic; Division of Pulmonary Medicine, Department of Pediatrics; Departments of Pharmacy and Biostatistics; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington; and Cystic Fibrosis Therapeutic Development Network Coordinating Center, Children's Hospital and Regional Medical Center, Seattle, Washington Correspondence and requests for reprints should be addressed to Michal Kulich, Ph.D., Department of Probability and Mathematical Statistics, Charles University, Sokolovska 83, CZ-186 75 Praha 8, Czech Republic. E-mail: kulich{at}karlin.mff.cuni.cz Rationale: Forced expiratory volume in one second (FEV1), an important measure of pulmonary disease severity in patients with cystic fibrosis (CF), is frequently expressed as a percentage of a predicted value derived from a healthy reference population. There are limitations to comparing the lung function of a patient with CF to that of healthy control subjects, and potential advantages to comparing it to that of other patients with CF. Objective: To estimate CF-specific percentiles of FEV1 as functions of height, age, and sex. Methods: We used 287,108 FEV1 observations among more than 21,000 patients with CF in the CF Foundation National Patient Registry between 1994 and 2001. The percentiles were estimated using quantile regression methods. Results: FEV1 percentile "growth grids" are presented, allowing comparison of an individual's FEV1 to that of patients with CF of the same sex, age, and height. Their potential uses in clinical practice and research are illustrated. Conclusions: CF-specific reference equations allow individual patients' FEV1 to be placed in the context of the distribution of lung function of their peers with CF, and should improve generalizability of CF clinical trials by setting entry criteria that are equitable across sex and age ranges. They may serve as a useful adjunct to conventional reference equations.
Key Words: cystic fibrosis • lung function • percentile • reference equations This article has been cited by other articles:
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