help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on June 16, 2005, doi:10.1164/rccm.200407-955OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200407-955OCv1
172/6/693    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scichilone, N.
Right arrow Articles by Togias, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scichilone, N.
Right arrow Articles by Togias, A.
American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 693-699, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200407-955OC

Inhaled Corticosteroids and the Beneficial Effect of Deep Inspiration in Asthma

Nicola Scichilone, Solbert Permutt, Vincenzo Bellia and Alkis Togias

Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland; and Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell'Apparato Respiratorio, University of Palermo, Palermo, Italy

Correspondence and requests for reprints should be addressed to Alkis Togias, M.D., Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224. E-mail: atogias{at}jhmi.edu

Deep inspiration–induced bronchoprotection and bronchodilation are impaired in asthma. We evaluated the effect of inhaled glucocorticosteroids on these phenomena. Two groups of subjects with asthma, 9 with moderate/severe hyperresponsiveness to methacholine, and 12 with mild/borderline hyperresponsiveness to methacholine, received inhaled fluticasone (880 µg daily) for 12 weeks. Serial bronchoprovocations were performed at Weeks 0, 6, and 12. The impact of deep inspirations on the airway response to methacholine was evaluated on the basis of inspiratory vital capacity and FEV1. Fluticasone produced a wide spectrum of changes in the beneficial effects of deep inspiration, but the mean changes were not significant. The magnitude of the steroid-induced changes in bronchoprotection by deep inspiration correlated with baseline log PC20 (the provocative concentration of methacholine causing a 20% fall in FEV1; higher log PC20 predicted improvement of the deep inspiration effect). The steroid-induced changes led to the emergence of strong positive correlations between the effects of deep inspiration and the methacholine log PC20 that did not exist at baseline. We conclude that deep inspiration–induced bronchoprotection can be restored by inhaled glucocorticosteroids only in individuals with mild hyperresponsiveness. After steroid treatment, the beneficial effects of deep inspiration become significant determinants of the magnitude of airway hyperresponsiveness.

Key Words: airway hyperresponsiveness • asthma • deep inspiration • fluticasone • methacholine




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
C. G. Irvin and J. H. T. Bates
Physiologic Dysfunction of the Asthmatic Lung: What's Going On Down There, Anyway?
Proceedings of the ATS, May 1, 2009; 6(3): 306 - 311.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. T. Bates, A. Cojocaru, and L. K. A. Lundblad
Bronchodilatory effect of deep inspiration on the dynamics of bronchoconstriction in mice
J Appl Physiol, November 1, 2007; 103(5): 1696 - 1705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Berend and C. Salome
Can a Deep Breath Blow Away the Fog Surrounding Airway Hyperresponsiveness?
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 109 - 111.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. Slats, K. Janssen, A. van Schadewijk, D. T. van der Plas, R. Schot, J. G. van den Aardweg, J. C. de Jongste, P. S. Hiemstra, T. Mauad, K. F. Rabe, et al.
Bronchial Inflammation and Airway Responses to Deep Inspiration in Asthma and Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 121 - 128.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R. Shaaban, B. Leynaert, D. Soussan, J. M Anto, S. Chinn, R. de Marco, J. Garcia-Aymerich, J. Heinrich, C. Janson, D. Jarvis, et al.
Physical activity and bronchial hyperresponsiveness: European Community Respiratory Health Survey II
Thorax, May 1, 2007; 62(5): 403 - 410.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. W. Cockcroft
Deep inhalation bronchodilation and oral corticosteroids in asthma.
Chest, July 1, 2006; 130(1): 7 - 8.
[Full Text] [PDF]

Home page
 ChestHome page
A. M. Slats, J. K. Sont, R. H.C.J. van Klink, E. H.D. Bel, and P. J. Sterk
Improvement in bronchodilation following deep inspiration after a course of high-dose oral prednisone in asthma.
Chest, July 1, 2006; 130(1): 58 - 65.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. Wenzel and R. Covar
Update in asthma 2005.
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 698 - 706.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  New Orleans Int'l Conf