help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on June 3, 2005, doi:10.1164/rccm.200501-010OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200501-010OCv1
172/5/552    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Raby, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Raby, B. A.
American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 552-558, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200501-010OC

Original Article

Paternal History of Asthma and Airway Responsiveness in Children with Asthma

Benjamin A. Raby, Kristel Van Steen, Juan C. Celedón, Augusto A. Litonjua, Christoph Lange, Scott T. Weiss for the CAMP Research Group*

Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital; Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center; Harvard Medical School; Department of Biostatistics, Harvard School of Public Health; and Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Benjamin Raby, M.D.C.M., M.P.H., Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115. E-mail: benjamin.raby{at}channing.harvard.edu

Rationale: Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma. Objectives: We evaluated this relationship in 1,041 children with asthma participating in a randomized trial of antiinflammatory medications (the Childhood Asthma Management Program [CAMP]). Methods: Methacholine challenge testing was performed before treatment randomization and once per year over an average of 4.5 years postrandomization. Cross-sectional and longitudinal repeated measures analyses were performed to model the relationship between PC20 (the methacholine concentration causing a 20% fall in FEV1) with maternal, paternal, and joint parental histories of asthma. Models were adjusted for potential confounders. Measurements and Main Results: At baseline, AHR was strongly associated with a paternal history of asthma. Children with a paternal history of asthma demonstrated significantly greater AHR than those without such history (median logePC20, 0.84 vs. 1.13; p = 0.006). Although maternal history of asthma was not associated with AHR, children with two parents with asthma had greater AHR than those with no parents with asthma (median logePC20, 0.52 vs. 1.17; p = 0.0008). Longitudinal multivariate analysis of the relation between paternal history of asthma and AHR using repeated PC20 measurements over 44 months postrandomization confirmed a significant association between paternal history of asthma and AHR among children in CAMP. Conclusions: Our findings suggest that the genetic contribution of the father is associated with AHR, an important determinant of disease severity among children with asthma.

Key Words: airway responsiveness • asthma • genetics • longitudinal analysis • parent of origin




This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
M.-J. Martel, E. Rey, J.-L. Malo, S. Perreault, M.-F. Beauchesne, A. Forget, and L. Blais
Determinants of the Incidence of Childhood Asthma: A Two-Stage Case-Control Study
Am. J. Epidemiol., November 24, 2008; (2008) kwn309v1.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. P. Ly, M. E. Soto-Quiros, L. Avila, G. M. Hunninghake, B. A. Raby, D. Laskey, J. S. Sylvia, and J. C. Celedon
Paternal Asthma, Mold Exposure, and Increased Airway Responsiveness Among Children With Asthma in Costa Rica
Chest, January 1, 2008; 133(1): 107 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. C. Teerlink, M. J. Hegewald, and L. A. Cannon-Albright
A Genealogical Assessment of Heritable Predisposition to Asthma Mortality
Am. J. Respir. Crit. Care Med., November 1, 2007; 176(9): 865 - 870.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
D. M. Roden, R. B. Altman, N. L. Benowitz, D. A. Flockhart, K. M. Giacomini, J. A. Johnson, R. M. Krauss, H. L. McLeod, M. J. Ratain, M. V. Relling, et al.
Pharmacogenomics: Challenges and Opportunities.
Ann Intern Med, November 21, 2006; 145(10): 749 - 757.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. T. Cohen, J. C. Celedon, V. J. Hinckson, C. D. Ramsey, D. B. Wakefield, S. T. Weiss, and M. M. Cloutier
Health-care use among puerto rican and african-american children with asthma.
Chest, August 1, 2006; 130(2): 463 - 471.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. C. TePas, A. A. Litonjua, J. C. Celedon, D. Sredl, and D. R. Gold
Sensitization to Aeroallergens and Airway Hyperresponsiveness at 7 Years of Age
Chest, June 1, 2006; 129(6): 1500 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. Wenzel and R. Covar
Update in asthma 2005.
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 698 - 706.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  2009/2010 ATS Fellows Career Development Awards