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Published ahead of print on May 13, 2004, doi:10.1164/rccm.200308-1073WS
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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 567-571, (2004)
© 2004 American Thoracic Society
doi: 10.1164/rccm.200308-1073WS

NHLBI Workshop

Future Directions in Sarcoidosis Research

Summary of an NHLBI Working Group

William J. Martin, II, Michael C. Iannuzzi, Dorothy B. Gail and Hannah H. Peavy

College of Medicine, University of Cincinnati, Cincinnati, Ohio; Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, New York; and Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

Correspondence and requests for reprints should be addressed to Hannah H. Peavy, M.D., Division of Lung Diseases, National Heart, Lung, and Blood Institute, Two Rockledge Center, Suite 10018, 6701 Rockledge Drive, MSC 7952, Bethesda, MD 20892-7952. E-mail: peavyh{at}nih.gov

Sarcoidosis is a systemic granulomatous disease of unknown etiology that primarily affects the lungs. The etiology remains unclear; however, environmental, genetic, ethnic, and familial factors probably modify expression of the disease. As an example, African Americans are at greater risk of mortality and morbidity than are white Americans, and more often have a family history of sarcoidosis. Most patients with sarcoidosis recover spontaneously, but some develop chronic, debilitating disease. Corticosteroids and other drugs, although effective at controlling disease activity, may not influence the overall course of disease. Because of the many uncertainties about the pathogenesis, course, and management of sarcoidosis, the National Heart, Lung, and Blood Institute convened a working group to identify future research directions and opportunities for sarcoidosis. These include developing a tissue bank, using novel methods to identify genetic factors, studying the immunopathogenesis with human tissue and animal models, exploring new approaches to diagnose and manage disease, and, finally, conducting randomized controlled trials to assess new therapies.

Key Words: environmental • genetics • granuloma • lung disease • National Institutes of Health (United States)




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