Published ahead of print on January 12, 2004, doi:10.1164/rccm.200306-779OC
American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 816-821, (2004)
© 2004 American Thoracic Society
Effect of Ambient Air Pollution on Pulmonary Exacerbations and Lung Function in Cystic Fibrosis
Christopher H. Goss,
Stacey A. Newsom,
Jonathan S. Schildcrout,
Lianne Sheppard and
Joel D. Kaufman
Department of Medicine; Department of Environmental and Occupational Health Sciences; and Department of Biostatistics, University of Washington, Seattle, Washington
Correspondence and requests for reprints should be addressed to Christopher H. Goss, M.D., M.S., University of Washington Medical Center, Campus Box 356522, 1959 N.E. Pacific, Seattle, WA 98195. E-mail: goss{at}u.washington.edu
Information concerning the impact of environmental factors on cystic fibrosis (CF) is limited. We conducted a cohort study to assess the impact of air pollutants in CF. The study included patients over the age of 6 years enrolled in the Cystic Fibrosis Foundation National Patient Registry in 1999 and 2000. Exposure was assessed by linking air pollution values from the Aerometric Information Retrieval System with the patients' home zip code. After adjusting for confounders, a 10 µg/m3 rise in particulate matter (both with a median aerodynamic diameter of 10 µm (PM10) or less and with an aerodynamic diameter of 2.5 µm or less (PM2.5) was associated with an 8% (95% confidence interval [CI], 2–15%) and 21% (95% CI, 7–33%) increase in the odds of two or more exacerbations, respectively; a 10-ppb rise in ozone was associated with a 10% (95% CI, 3–17%) increase in odds of two or more exacerbations. For every increase in PM2.5 of 10 µg/m3, there was an associated fall in FEV1 of 24 ml (7–40) (95% CI) after adjusting for confounders. PM2.5's association with mortality did not achieve statistical significance (adjusted RR = 1.32 per 10 µg/m3 0.91–1.93; 95% CI). Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF.
Key Words: cystic fibrosis • air pollutants • survival • outcome • pulmonary exacerbation
This article has been cited by other articles:
|
|
|
|
 
R. A. Johnston, J. P. Mizgerd, L. Flynt, L. J. Quinton, E. S. Williams, and S. A. Shore
Type I Interleukin-1 Receptor Is Required for Pulmonary Responses to Subacute Ozone Exposure in Mice
Am. J. Respir. Cell Mol. Biol.,
October 1, 2007;
37(4):
477 - 484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. L. Vanscoy, S. M. Blackman, J. M. Collaco, A. Bowers, T. Lai, K. Naughton, M. Algire, R. McWilliams, S. Beck, J. Hoover-Fong, et al.
Heritability of Lung Disease Severity in Cystic Fibrosis
Am. J. Respir. Crit. Care Med.,
May 15, 2007;
175(10):
1036 - 1043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H Goss and J. L Burns
Exacerbations in cystic fibrosis {middle dot} 1: Epidemiology and pathogenesis
Thorax,
April 1, 2007;
62(4):
360 - 367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Boyle
Strategies for Identifying Modifier Genes in Cystic Fibrosis
Proceedings of the ATS,
January 1, 2007;
4(1):
52 - 57.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Soberanes, V. Panduri, G. M. Mutlu, A. Ghio, G. R. S. Bundinger, and D. W. Kamp
p53 Mediates Particulate Matter-induced Alveolar Epithelial Cell Mitochondria-regulated Apoptosis
Am. J. Respir. Crit. Care Med.,
December 1, 2006;
174(11):
1229 - 1238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Poster presentations
Thorax,
December 1, 2005;
60(suppl_2):
ii53 - ii120.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bush, F. Accurso, W. MacNee, S. C. Lazarus, and E. Abraham
Cystic Fibrosis, Pediatrics, Control of Breathing, Pulmonary Physiology and Anatomy, and Surfactant Biology in AJRCCM in 2004
Am. J. Respir. Crit. Care Med.,
March 15, 2005;
171(6):
545 - 553.
[Full Text]
[PDF]
|
|
|
Copyright © 2004 American Thoracic Society
|
|
|
