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Published ahead of print on November 14, 2003, doi:10.1164/rccm.200302-278OC
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American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 615-622, (2004)
© 2004 American Thoracic Society

Age-specific Relationship between CD14 and Atopy in a Cohort Assessed from Age 8 to 25 Years

Anne R. O'Donnell, Brett G. Toelle, Guy B. Marks, Catherine M. Hayden, Ingrid A. Laing, Jennifer K. Peat, Jack Goldblatt and Peter N. Le Souëf

Department of Paediatrics, University of Western Australia, Children's Hospital Medical Centre, Perth; and The Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia

Correspondence and requests for reprints should be addressed to Peter N. Le Souëf, M.D., F.R.A.C.P., University Department of Paediatrics, Children's Hospital Medical Centre, Princess Margaret Hospital, G.P.O. Box D184, Perth, WA, Australia 6001. E-mail: peterles{at}ichr.uwa.edu.au

CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected population with extensive longitudinal data was used to test the hypothesis that CD14 C-159T was associated with early-onset atopy. A total of 305 subjects were assessed on up to seven occasions between ages 8 and 25 years by questionnaire, histamine challenge, and skin prick test. For atopy, airway hyperresponsiveness (AHR), and wheeze, each subject was classified as having early onset, late onset, or no disease onset during follow-up. Compared with subjects with -159CT and -159TT, subjects with -159CC had an odds ratio of 2.2 (p = 0.018) for early-onset atopy and an odds ratio of 2.6 (p = 0.019) for early-onset AHR. Cross-sectional analysis showed increased prevalence of -159CC in subjects with atopy and AHR in childhood but not adulthood. These data suggest that the influence of CD14 -159C on the atopic phenotype may be age specific, exerting an effect during midchildhood, which is no longer apparent by early adulthood.

Key Words: longitudinal • gene • polymorphism • asthma




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