help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on October 2, 2003, doi:10.1164/rccm.200302-239OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200302-239OCv1
169/1/105    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Watanabe, T.
Right arrow Articles by Nishizaki, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Watanabe, T.
Right arrow Articles by Nishizaki, K.
American Journal of Respiratory and Critical Care Medicine Vol 169. pp. 105-112, (2004)
© 2004 American Thoracic Society

Roles of Fc{gamma}RIIB in Nasal Eosinophilia and IgE Production in Murine Allergic Rhinitis

Tohru Watanabe, Mitsuhiro Okano, Hisashi Hattori, Tadashi Yoshino, Nobuaki Ohno, Nobuo Ohta, Yuji Sugata, Yorihisa Orita, Toshiyuki Takai and Kazunori Nishizaki

Departments of Otolaryngology-Head and Neck Surgery, and Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama; Department of Otolaryngology and Medical Zoology, Nagoya City University Medical School, Nagoya; and Department of Experimental Immunology, Institute of Development, Aging, and Cancer, Sendai, Japan

Correspondence and requests for reprints should be addressed to Mitsuhiro Okano, M.D., Ph.D., Department of Otolaryngology-Head and Neck Surgery, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700–8558, Japan. E-mail: mokano{at}cc.okayama-u.ac.jp

The low-affinity IgG Fc receptor, Fc{gamma}RIIB, displays inhibitory potential in experimental models such as autoimmune diseases. However, whether this receptor is involved in the onset of allergic diseases remains unknown. This study examines the role of Fc{gamma}RIIB in the initiation of allergic rhinitis in mice. Repeated intranasal sensitization with Schistosoma mansoni egg antigen (SEA) induced SEA-specific IgE and marked nasal eosinophilia in high-responder BALB/c mice. Fc{gamma}RIIB gene-deficient (-/-) BALB/c mice displayed severe eosinophilia compared with that of wild-type counterparts. However, Fc{gamma}RIIB -/- mice conversely produced less SEA-specific IgE. The production of interleukin (IL)-4 but not of IL-5 or IFN-{gamma} by nasal mononuclear cells was also decreased in Fc{gamma}RIIB -/- mice, suggesting that the exacerbation of nasal eosinophila in Fc{gamma}RIIB -/- mice is independent of the local IL-5 levels. The findings in low responder C57BL/6 mice were similar. In addition, nasal eosinophilia in Fc{gamma}RIIB -/- mice passively sensitized with SEA was exacerbated, and conversely, specific IgE production was inhibited after a nasal challenge. These results suggest that Fc{gamma}RIIB plays a regulatory role in the initiation of allergic rhinitis that is independent of either mouse strain or type of sensitization.

Key Words: Fc receptor • rhinitis • mouse • IgE • eosinophil




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. S. Nakashima, C. M. Prado, T. Lancas, V. C. Ruiz, D. I. Kasahara, E. A. Leick-Maldonado, M. Dolhnikoff, M. A. Martins, and I. F. L. C. Tiberio
Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs
J Appl Physiol, June 1, 2008; 104(6): 1778 - 1785.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Angeli, C. M. Prado, D. G. Xisto, P. L. Silva, C. P. Passaro, H. D. Nakazato, E. A. Leick-Maldonado, M. A. Martins, P. R. M. Rocco, and I. F. L. C. Tiberio
Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammation
Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1197 - L1205.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. P. Vieira, A. C. S. Duarte, R. C. Claudino, A. Perini, A. B. G. Santos, H. T. Moriya, F. M. Arantes-Costa, M. A. Martins, C. R. F. Carvalho, and M. Dolhnikoff
Creatine Supplementation Exacerbates Allergic Lung Inflammation and Airway Remodeling in Mice
Am. J. Respir. Cell Mol. Biol., December 1, 2007; 37(6): 660 - 667.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Lancas, D. I. Kasahara, C. M. Prado, I. F. L. C. Tiberio, M. A. Martins, and M. Dolhnikoff
Comparison of early and late responses to antigen of sensitized guinea pig parenchymal lung strips
J Appl Physiol, May 1, 2006; 100(5): 1610 - 1616.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Fabbri, S. P. Peters, I. Pavord, S. E. Wenzel, S. C. Lazarus, W. MacNee, F. Lemaire, and E. Abraham
Allergic Rhinitis, Asthma, Airway Biology, and Chronic Obstructive Pulmonary Disease in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 686 - 698.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  New Orleans Int'l Conf