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Published ahead of print on May 8, 2003, doi:10.1164/rccm.200211-1343OC
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American Journal of Respiratory and Critical Care Medicine Vol 168. pp. 323-329, (2003)
© 2003 American Thoracic Society

The Sarcoidosis Health Questionnaire

A New Measure of Health-related Quality of Life

Christopher E. Cox, James F. Donohue, Cynthia D. Brown, Yash P. Kataria and Marc A. Judson

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill; Division of Pulmonary and Critical Care Medicine, Department of Medicine, East Carolina University, Greenville, North Carolina; and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina

Correspondence and requests for reprints should be addressed to Christopher Cox, M.D., M.P.H., Duke University Medical Center, Division of Pulmonary and Critical Care Medicine, Box 3221, Durham, NC 27710. E-mail: christopher.cox{at}duke.edu

The Sarcoidosis Health Questionnaire (SHQ) is a health-related quality-of-life (HRQL) instrument we designed in a two-part study to allow patients to describe their satisfaction with life as it is affected by sarcoidosis. In the Development Study, we created the SHQ from a 151-item pool generated from interviews with 107 patients, a search of the relevant literature, and discussion with sarcoidosis experts. Using clinical impact methodology and the questionnaire responses of a separate group of 149 patients, we reduced the total number of items to 29. The final SHQ has three domains: Daily Functioning, Physical Functioning, and Emotional Functioning. In the Validation Study, performed with a different group of 111 patients, we found that the SHQ had good internal consistency reliability, as well as evidence of content, criterion, and construct validity based on its comparison with other measures of HRQL (Medical Outcomes Study 36-Item short form and the St. George's Respiratory Questionnaire) and of mental health (the Center for Epidemiologic Study—Depression Scale), as well as with clinical variables including spirometry. The SHQ alone was sensitive to differences in HRQL based on the number of involved organ systems. In conclusion, we have developed a self-completed HRQL questionnaire for U.S. patients with sarcoidosis.

Key Words: health status indicators • quality of life • questionnaires • sarcoidosis




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