Published ahead of print on January 16, 2003, doi:10.1164/rccm.200206-552OC
© 2003 American Thoracic Society
Effects of Theophylline on Ventilatory Poststimulus Potentiation in Patients with Brain DamageDepartment of Intensive Care Medicine and Department of Thoracic Medicine, University Hospital of Heraklion, University of Crete, Heraklion, Crete, Greece Correspondence and requests for reprints should be addressed to Dimitris Georgopoulos, M.D., University Hospital of Heraklion, University of Crete, Heraklion, 711 10, Crete, Greece. E-mail: georgop{at}med.uoc.gr Patients with brain damage, in contrast to normal subjects, exhibit a significant ventilatory undershoot when brief hypocapnic hypoxia is terminated abruptly by hyperoxia. This has been attributed to an impairment of activation of short-term potentiation, a brain stem mechanism promoting breathing stability. We hypothesized that in these patients theophylline, a drug that stabilizes breathing, may affect short-term potentiation. Eight stable patients with brain damage and 10 normal adults were studied. Activation of short-term potentiation was examined by brief exposure to hypoxia followed by hyperoxia after pretreatment with placebo or theophylline. Both in patients and normal subjects at the end of hypoxia ventilation increased to a similar magnitude with and without theophylline. In normal subjects independent of pretreatment, when hypoxia was terminated abruptly by hyperoxia, ventilation declined slowly to baseline without an undershoot, indicating activation of short-term potentiation. In patients with placebo, ventilation upon switching to hyperoxia exhibited a significant undershoot. This undershoot was significantly attenuated by theophylline, although compared with normal subjects, a slight hypoventilation was observed. We conclude that in patients with brain damage, theophylline largely prevents the hyperoxic drop of ventilation, presumably by affecting the activation of short-term potentiation. This may underlie the beneficial effect of theophylline on breathing stability.
Key Words: periodic breathing • ventilation • hypoxia • hyperoxia This article has been cited by other articles:
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