help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on October 17, 2002, doi:10.1164/rccm.200208-789OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200208-789OCv1
167/2/199    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flood-Page, P. T.
Right arrow Articles by Robinson, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flood-Page, P. T.
Right arrow Articles by Robinson, D. S.
American Journal of Respiratory and Critical Care Medicine Vol 167. pp. 199-204, (2003)
© 2003 American Thoracic Society

Original Article

Eosinophil's Role Remains Uncertain as Anti–Interleukin-5 only Partially Depletes Numbers in Asthmatic Airway

Patrick T. Flood-Page*, Andrew N. Menzies-Gow*, A. Barry Kay and Douglas S. Robinson

Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom

Correspondence and requests for reprints should be addressed to A. Barry Kay, M.D., Allergy and Clinical Immunology, National Heart and Lung Institute Faculty of Medicine, Imperial College Dovehouse Street, London SW3 6LY, UK. E-mail: a.b.kay{at}ic.ac.uk

The role of eosinophils as effector cells in asthma pathogenesis has been questioned since an anti–interleukin (IL)-5 monoclonal antibody (mepolizumab), which depleted blood and sputum eosinophils, failed to inhibit allergen-induced bronchoconstriction and airway hyperresponsiveness. However, the effect of IL-5 blockade on tissue eosinophils was not examined. We sought to determine whether mepolizumab depletes airway tissue eosinophils and their products. Twenty-four patients with mild asthma received three intravenous doses of either 750 mg of mepolizumab or placebo in a randomized, double-blind, parallel-group fashion over 20 weeks. Mepolizumab produced a median decrease from baseline of 55% for airway eosinophils (interquartile range, 29–89%; p = 0.009 versus placebo), 52% for bone marrow eosinophils (45–76%, p = 0.003), and 100% for blood eosinophils (range, 67–100%, p = 0.02). Mepolizumab had no appreciable effect on bronchial mucosal staining of eosinophil major basic protein. There were no significant changes in clinical measures of asthma (airway hyperresponsiveness, FEV1, and peak flow recordings) between the mepolizumab and placebo-treated groups. Anti–IL-5 treatment reduces but does not deplete airway or bone marrow eosinophils. The role of the eosinophil remains uncertain. Further clinical studies in asthma with more effective antieosinophil strategies are required.

Key Words: eosinophils • asthma • anti–interleukin-5




This article has been cited by other articles:


Home page
 J. Immunol.Home page
D. J. Song, J. Y. Cho, S. Y. Lee, M. Miller, P. Rosenthal, P. Soroosh, M. Croft, M. Zhang, A. Varki, and D. H. Broide
Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling
J. Immunol., October 15, 2009; 183(8): 5333 - 5341.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. A. Plager, M. D. P. Davis, A. G. Andrews, M. J. Coenen, T. J. George, G. J. Gleich, and K. M. Leiferman
Eosinophil Ribonucleases and Their Cutaneous Lesion-Forming Activity
J. Immunol., September 15, 2009; 183(6): 4013 - 4020.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. G. Woodruff, B. Modrek, D. F. Choy, G. Jia, A. R. Abbas, A. Ellwanger, J. R. Arron, L. L. Koth, and J. V. Fahy
T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma
Am. J. Respir. Crit. Care Med., September 1, 2009; 180(5): 388 - 395.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Svensson, E. Redvall, M. Johnsson, A.-L. Stenfeldt, C. Dahlgren, and C. Wenneras
Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophils
J. Leukoc. Biol., August 1, 2009; 86(2): 327 - 336.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. Zarogiannis, K. I. Gourgoulianis, K. Kostikas, A. Szczeklik, G. J. Gleich, I. D. Pavord, A. J. Wardlaw, P. Haldar, P. Nair, F. E. Hargreave, et al.
Anti-Interleukin-5 Therapy and Severe Asthma
N. Engl. J. Med., June 11, 2009; 360(24): 2576 - 2578.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. F. Lemanske Jr.
Asthma Therapies Revisited: What Have We Learned?
Proceedings of the ATS, May 1, 2009; 6(3): 312 - 315.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. Haldar, C. E. Brightling, B. Hargadon, S. Gupta, W. Monteiro, A. Sousa, R. P. Marshall, P. Bradding, R. H. Green, A. J. Wardlaw, et al.
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
N. Engl. J. Med., March 5, 2009; 360(10): 973 - 984.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. Nair, M. M.M. Pizzichini, M. Kjarsgaard, M. D. Inman, A. Efthimiadis, E. Pizzichini, F. E. Hargreave, and P. M. O'Byrne
Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia
N. Engl. J. Med., March 5, 2009; 360(10): 985 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. A. Doherty, P. Soroosh, D. H. Broide, and M. Croft
CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling
Am J Physiol Lung Cell Mol Physiol, February 1, 2009; 296(2): L229 - L235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. C. Verhein, D. B. Jacoby, and A. D. Fryer
IL-1 Receptors Mediate Persistent, but Not Acute, Airway Hyperreactivity to Ozone in Guinea Pigs
Am. J. Respir. Cell Mol. Biol., December 1, 2008; 39(6): 730 - 738.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ueki, G. Mahemuti, H. Oyamada, H. Kato, J. Kihara, M. Tanabe, W. Ito, T. Chiba, M. Takeda, H. Kayaba, et al.
Retinoic Acids Are Potent Inhibitors of Spontaneous Human Eosinophil Apoptosis
J. Immunol., December 1, 2008; 181(11): 7689 - 7698.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. W. Johansson, E. A. B. Kelly, W. W. Busse, N. N. Jarjour, and D. F. Mosher
Up-Regulation and Activation of Eosinophil Integrins in Blood and Airway after Segmental Lung Antigen Challenge
J. Immunol., June 1, 2008; 180(11): 7622 - 7635.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
K. Polzer, T. Karonitsch, T. Neumann, G. Eger, C. Haberler, A. Soleiman, B. Hellmich, E. Csernok, J. Distler, B. Manger, et al.
Eotaxin-3 is involved in Churg-Strauss syndrome - a serum marker closely correlating with disease activity
Rheumatology, June 1, 2008; 47(6): 804 - 808.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. A. Hanania
Targeting Airway Inflammation in Asthma: Current and Future Therapies
Chest, April 1, 2008; 133(4): 989 - 998.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. E. Rothenberg, A. D. Klion, F. E. Roufosse, J. E. Kahn, P. F. Weller, H.-U. Simon, L. B. Schwartz, L. J. Rosenwasser, J. Ring, E. F. Griffin, et al.
Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab
N. Engl. J. Med., March 20, 2008; 358(12): 1215 - 1228.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
E. A. Jacobsen, S. I. Ochkur, R. S. Pero, A. G. Taranova, C. A. Protheroe, D. C. Colbert, N. A. Lee, and J. J. Lee
Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells
J. Exp. Med., March 17, 2008; 205(3): 699 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-C. Su, M. S. Rolph, N. G. Hansbro, C. R. Mackay, and W. A. Sewell
Granulocyte-Macrophage Colony-Stimulating Factor Is Required for Bronchial Eosinophilia in a Murine Model of Allergic Airway Inflammation
J. Immunol., February 15, 2008; 180(4): 2600 - 2607.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. L. Asquith, H. S. Ramshaw, P. M. Hansbro, K. W. Beagley, A. F. Lopez, and P. S. Foster
The IL-3/IL-5/GM-CSF Common Receptor Plays a Pivotal Role in the Regulation of Th2 Immunity and Allergic Airway Inflammation
J. Immunol., January 15, 2008; 180(2): 1199 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Siddiqui, F. Hollins, S. Saha, and C. E. Brightling
Inflammatory cell microlocalisation and airway dysfunction: cause and effect?
Eur. Respir. J., December 1, 2007; 30(6): 1043 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. M. O'Byrne
The Demise of Anti IL-5 for Asthma, or Not
Am. J. Respir. Crit. Care Med., December 1, 2007; 176(11): 1059 - 1060.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Flood-Page, C. Swenson, I. Faiferman, J. Matthews, M. Williams, L. Brannick, D. Robinson, S. Wenzel, W. Busse, T. T. Hansel, et al.
A Study to Evaluate Safety and Efficacy of Mepolizumab in Patients with Moderate Persistent Asthma
Am. J. Respir. Crit. Care Med., December 1, 2007; 176(11): 1062 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. H. Walters, D. W. Reid, D. P. Johns, and C. Ward
Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling
Eur. Respir. J., September 1, 2007; 30(3): 574 - 588.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Phipps, C. E. Lam, S. Mahalingam, M. Newhouse, R. Ramirez, H. F. Rosenberg, P. S. Foster, and K. I. Matthaei
Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus
Blood, September 1, 2007; 110(5): 1578 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Nakagome, M. Dohi, K. Okunishi, R. Tanaka, T. Kouro, M. R. Kano, K. Miyazono, J.-i. Miyazaki, K. Takatsu, and K. Yamamoto
IL-5-Induced Hypereosinophilia Suppresses the Antigen-Induced Immune Response via a TGF-beta-Dependent Mechanism
J. Immunol., July 1, 2007; 179(1): 284 - 294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Camateros, M. Tamaoka, M. Hassan, R. Marino, J. Moisan, D. Marion, M.-C. Guiot, J. G. Martin, and D. Radzioch
Chronic Asthma-induced Airway Remodeling Is Prevented by Toll-like Receptor-7/8 Ligand S28463
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1241 - 1249.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Kallinich, K. C. Beier, U. Wahn, P. Stock, and E. Hamelmann
T-cell co-stimulatory molecules: their role in allergic immune reactions
Eur. Respir. J., June 1, 2007; 29(6): 1246 - 1255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. G. Verbout, J. K. Lorton, D. B. Jacoby, and A. D. Fryer
Atropine pretreatment enhances airway hyperreactivity in antigen-challenged guinea pigs through an eosinophil-dependent mechanism
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1126 - L1135.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Main, R. Handy, J. Wilton, S. Smith, L. Williams, L. D. Fou, J. Andrews, L. A. Conroy, R. May, I. Anderson, et al.
A Potent Human Anti-Eotaxin1 Antibody, CAT-213: Isolation by Phage Display and in Vitro and in Vivo Efficacy
J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1395 - 1404.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. C. Fulkerson, C. A. Fischetti, M. L. McBride, L. M. Hassman, S. P. Hogan, and M. E. Rothenberg
A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
PNAS, October 31, 2006; 103(44): 16418 - 16423.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. M. Swartz, K. D. Dyer, A. W. Cheever, T. Ramalingam, L. Pesnicak, J. B. Domachowske, J. J. Lee, N. A. Lee, P. S. Foster, T. A. Wynn, et al.
Schistosoma mansoni infection in eosinophil lineage-ablated mice
Blood, October 1, 2006; 108(7): 2420 - 2427.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. R. Barthel, N. N. Jarjour, D. F. Mosher, and M. W. Johansson
Dissection of the Hyperadhesive Phenotype of Airway Eosinophils in Asthma
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 378 - 386.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. M. O'Byrne
Cytokines or their antagonists for the treatment of asthma.
Chest, July 1, 2006; 130(1): 244 - 250.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. M. Gorska, O. Cen, Q. Liang, S. J. Stafford, and R. Alam
Differential Regulation of Interleukin 5-stimulated Signaling Pathways by Dynamin
J. Biol. Chem., May 19, 2006; 281(20): 14429 - 14439.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Lopez, V. del Pozo, T. Miguel, B. Sastre, C. Seoane, E. Civantos, E. Llanes, M. L. Baeza, P. Palomino, B. Cardaba, et al.
Inhibition of Chronic Airway Inflammation and Remodeling by Galectin-3 Gene Therapy in a Murine Model
J. Immunol., February 1, 2006; 176(3): 1943 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. M. Pope, N. Zimmermann, K. F. Stringer, M. L. Karow, and M. E. Rothenberg
The Eotaxin Chemokines and CCR3 Are Fundamental Regulators of Allergen-Induced Pulmonary Eosinophilia
J. Immunol., October 15, 2005; 175(8): 5341 - 5350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. K. Morgan, R. W. Costello, N. Durcan, P. J. Kingham, G. J. Gleich, W. G. McLean, and M.-T. Walsh
Diverse Effects of Eosinophil Cationic Granule Proteins on IMR-32 Nerve Cell Signaling and Survival
Am. J. Respir. Cell Mol. Biol., August 1, 2005; 33(2): 169 - 177.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. L. Chou, B. L. Daugherty, E. K. McKenna, W. M. Hsu, N. K. Tyler, C. G. Plopper, D. M. Hyde, E. S. Schelegle, L. J. Gershwin, and L. A. Miller
Chronic Aeroallergen during Infancy Enhances Eotaxin-3 Expression in Airway Epithelium and Nerves
Am. J. Respir. Cell Mol. Biol., July 1, 2005; 33(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Joetham, K. Takeda, C. Taube, N. Miyahara, A. Kanehiro, A. Dakhama, and E. W. Gelfand
Airway Hyperresponsiveness in the Absence of CD4+ T Cells after Primary but Not Secondary Challenge
Am. J. Respir. Cell Mol. Biol., July 1, 2005; 33(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
L. M. Fabbri
Does Mild Persistent Asthma Require Regular Treatment?
N. Engl. J. Med., April 14, 2005; 352(15): 1589 - 1591.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
R. K. Morgan, P. J. Kingham, M. T. Walsh, D. C. Curran, N. Durcan, W. G. McLean, and R. W. Costello
Eosinophil Adhesion to Cholinergic IMR-32 Cells Protects against Induced Neuronal Apoptosis
J. Immunol., November 15, 2004; 173(10): 5963 - 5970.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W.J. Elston, A.J. Whittaker, L.N. Khan, P. Flood-Page, C. Ramsay, P.K. Jeffery, and N.C. Barnes
Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma
Eur. Respir. J., September 1, 2004; 24(3): 375 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. Tanaka, M. Komai, K. Nagao, M. Ishizaki, D. Kajiwara, K. Takatsu, G. Delespesse, and H. Nagai
Role of Interleukin-5 and Eosinophils in Allergen-Induced Airway Remodeling in Mice
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 62 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Dent, C. Hadjicharalambous, T. Yoshikawa, R. L. C. Handy, J. Powell, I. K. Anderson, R. Louis, D. E. Davies, and R. Djukanovic
Contribution of Eotaxin-1 to Eosinophil Chemotactic Activity of Moderate and Severe Asthmatic Sputum
Am. J. Respir. Crit. Care Med., May 15, 2004; 169(10): 1110 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Kanazawa, S. Nomura, and J. Yoshikawa
Role of Microvascular Permeability on Physiologic Differences in Asthma and Eosinophilic Bronchitis
Am. J. Respir. Crit. Care Med., May 15, 2004; 169(10): 1125 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Papi
Investigating the steroids and long-acting {beta}2-agonists combination: why do we need more?
Eur. Respir. J., April 1, 2004; 23(4): 501 - 502.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. C. Grootendorst and K. F. Rabe
Mechanisms of Bronchial Hyperreactivity in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2004; 1(2): 77 - 87.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. Buhl and S. G. Farmer
Current and Future Pharmacologic Therapy of Exacerbations in Chronic Obstructive Pulmonary Disease and Asthma
Proceedings of the ATS, April 1, 2004; 1(2): 136 - 142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. Sitkauskiene, A.-K. Johansson, S. Sergejeva, S. Lundin, M. Sjostrand, and J. Lotvall
Regulation of Bone Marrow and Airway CD34+ Eosinophils by Interleukin-5
Am. J. Respir. Cell Mol. Biol., March 1, 2004; 30(3): 367 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Dorman, A. Efthimiadis, I. Babirad, R. M. Watson, J. A. Denburg, F. E. Hargreave, P. M. O'Byrne, and R. Sehmi
Sputum CD34+IL-5R{alpha}+ Cells Increase after Allergen: Evidence for In Situ Eosinophilopoiesis
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 573 - 577.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Dorman, R. Sehmi, G. M. Gauvreau, R. M. Watson, R. Foley, G. L. Jones, J. A. Denburg, M. D. Inman, and P. M. O'Byrne
Kinetics of Bone Marrow Eosinophilopoiesis and Associated Cytokines after Allergen Inhalation
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 565 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Maghni, C. Lemiere, H. Ghezzo, W. Yuquan, and J.-L. Malo
Airway Inflammation after Cessation of Exposure to Agents Causing Occupational Asthma
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 367 - 372.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2003
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 265 - 276.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. E. Brightling, I. D. Pavord, P. T. Flood-Page, A. N. Menzies-Gow, A. B. Kay, and D. S. Robinson
Eosinophils in Asthma and Airway Hyperresponsiveness
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 131 - 133.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. M. Abraham, A. Ahmed, I. Serebriakov, A. N. Carmillo, J. Ferrant, A. R. de Fougerolles, E. A. Garber, P. J. Gotwals, V. E. Koteliansky, F. Taylor, et al.
A Monoclonal Antibody to {alpha}1{beta}1 Blocks Antigen-induced Airway Responses in Sheep
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 97 - 104.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S.-G. Plotz, H.-U. Simon, U. Darsow, D. Simon, E. Vassina, S. Yousefi, R. Hein, T. Smith, H. Behrendt, and J. Ring
Use of an Anti-Interleukin-5 Antibody in the Hypereosinophilic Syndrome with Eosinophilic Dermatitis
N. Engl. J. Med., December 11, 2003; 349(24): 2334 - 2339.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Jeffery, S. Holgate, and S. Wenzel
Methods for the Assessment of Endobronchial Biopsies in Clinical Research: Application to Studies of Pathogenesis and the Effects of Treatment
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): S1 - 17.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. J. Holtzman
Drug Development for Asthma
Am. J. Respir. Cell Mol. Biol., August 1, 2003; 29(2): 163 - 171.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. B. Kay and A. Menzies-Gow
Eosinophils and Interleukin-5: The Debate Continues
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1586 - 1587.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Gregory, A. Kirchem, S. Phipps, P. Gevaert, C. Pridgeon, S. M. Rankin, and D. S. Robinson
Differential Regulation of Human Eosinophil IL-3, IL-5, and GM-CSF Receptor {alpha}-Chain Expression by Cytokines: IL-3, IL-5, and GM-CSF Down-Regulate IL-5 Receptor {alpha} Expression with Loss of IL-5 Responsiveness, but Up-Regulate IL-3 Receptor {alpha} Expression
J. Immunol., June 1, 2003; 170(11): 5359 - 5366.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. L. Hardy, L. Kenins, A. C. Drew, J. M. Rolland, and R. E. O'Hehir
Characterization of a Mouse Model of Allergy to a Major Occupational Latex Glove Allergen Hev b 5
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1393 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. W. Busse and E. A. E. B. Kelly
Is the Eosinophil a "Humpty Dumpty" Cell in Asthma?
Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 102 - 103.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2003 American Thoracic Society 		  SOTA, FL