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Published ahead of print on August 1, 2002, doi:10.1164/rccm.200205-421OC
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American Journal of Respiratory and Critical Care Medicine Vol 166. pp. 1099-1104, (2002)
© 2002 American Thoracic Society

Articles

Pulmonary Function Tests in Preschool Children with Cystic Fibrosis

Nicole Beydon, Francis Amsallem, Mireille Bellet, Michèle Boulé, Michèle Chaussain, André Denjean, Régis Matran, Isabelle Pin, Corinne Alberti and Claude Gaultier the French Paediatric PHRC Group

Departments of Physiology and Public Health of the Robert Debré Teaching Hospital; Physiology Departments of the Saint-Vincent-de-Paul Teaching Hospital and Trousseau Teaching Hospital, Paris; Pediatric Department, Arnaud de Villeneuve Teaching Hospital, Montpellier; Physiology Department, Morvan Teaching Hospital, Brest; Poitiers Teaching Hospital, Poitiers; Calmette Teaching Hospital, Lille; and Grenoble Teaching Hospital, Grenoble, France

Correspondence and requests for reprints should be addressed to Claude Gaultier, Service de Physiologie, Hopital Robert Debré, 48 Bd Serurier, 75019, Paris, France. E-mail: claude.gaultier{at}rdb.ap-hop-paris.fr

ABSTRACT

Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis (CF). The objective of this multicenter study was to compare pulmonary function in 39 preschool children with CF (height, 90–130 cm; 16 homozygous {Delta}F508) and in 79 healthy control children. Functional residual capacity (helium dilution technique) and expiratory interrupter resistance (Rintexp) (interrupter technique) were measured. As compared with control children, children with CF had significantly higher Rintexp, expressed as absolute values and as Z-scores (1.05 ± 0.36 versus 0.80 ± 0.20 kPa·L-1 · second, p < 0.0001; and 1.31 ± 1.72 versus 0.19 ± 0.97, p < 0.0001), and significantly lower specific expiratory interrupter conductance (1.29 ± 0.34 versus 1.63 ± 0.43 kPa-1 · second, p < 0.0001). The effect of the bronchodilator salbutamol on Rintexp was not significantly different between children with CF and control children. Rintexp Z-scores were significantly higher in children with CF who were exposed to passive smoke (n = 8) (p < 0.03). Children with CF and with a history of respiratory symptoms (n = 31) had significantly higher functional residual capacity Z-scores (p < 0.02) and lower specific expiratory interrupter conductance Z-scores (p < 0.04). Genotype did not influence the data. We conclude that Rintexp and functional residual capacity measurements may help to follow young children with CF who are unable to perform reproducible forced expiratory maneuvers.

Key Words: functional residual capacity • expiratory interrupter resistance • bronchodilator • genotype • passive smoke




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