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American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 1172, (2008)
© 2008 American Thoracic Society

Correspondence

Effects of Misclassification of Fume Exposure

From the Authors:

We appreciate the comment of Dr. Whitney on our article (1) and agree that there is a possibility of differential misclassification based upon subject recall bias. However, although self-reporting of "dust exposure" would have been at least as likely to be subject to recall bias, we did not find a dust exposure effect on rate of decline. Furthermore, in a separate analysis of cross-sectional baseline data, fume exposure was evaluated based upon a job exposure matrix independently of self-reported fume exposure; in this cross-sectional analysis, fume was associated with reduced FEV1 (2). Our longitudinal analysis included adjustment for baseline FEV1, so that differential misclassification due to recall bias would also contribute to underestimation of the actual regression coefficient relating FEV1 decline to fume exposure.

Philip Harber and Donald Tashkin

University of California, Los Angeles
Los Angeles, California

Eva Hnizdo

National Institute for Occupational Safety and Health
Morgantown, West Virginia

FOOTNOTES

Conflict of Interest Statement: None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

REFERENCES

  1. Harber P, Tashkin DP, Simmons M, Crawford L, Hnizdo E, Connett J; for the Lung Health Study Group. Effect of occupational exposures on decline of lung function in early chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;176:994–1000.[Abstract/Free Full Text]
  2. Harber P, Simmons M, Tashkin D, Hnizdo E, Crawford L, Connett J. Comparison of three methods for assigning exposure metrics for evaluating occupation effect upon COPD [abstract]. Proc Am Thorac Soc 2005;2:A818.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2008 American Thoracic Society