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American Journal of Respiratory and Critical Care Medicine Vol 173. pp. 359a, (2006)
© 2006 American Thoracic Society

Correspondence

Lack of Directly Observed Treatment Affects Tuberculosis Relapse Rates

From the Authors:

We agree with Dr. Frieden's comment on our recent article (1). Increasing or decreasing the likelihood of inconsistent treatment could decrease or increase the rate of tuberculosis (TB) recurrence, and therefore the incidence of active TB under highly active antiretroviral therapy (HAART) in adults with TB history at HAART start. In the conclusion section of our article, we suggested that further studies of TB risk factors in HAART-treated patients in sub-Saharan Africa should include TB past history at baseline. Frieden rightly points out that key characteristics of the previous TB episode should also be taken into consideration. This includes self-delivery of drugs, but also drug resistance and TB treatment regimen (2).

Catherine Seyler, Eugène Messou, Siaka Toure and Xavier Anglaret

Programme PAC-CI, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d'Ivoire and INSERM U593—Université Victor Segalen, Bordeaux 2, Bordeaux, France

FOOTNOTES

Conflict of Interest Statement: None of the authors have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

REFERENCES

  1. Seyler C, Toure S, Messou E, Bonard D, Gabillard D, Anglaret X. Risk factors for active tuberculosis after antiretroviral treatment initiation in Abidjan. Am J Respir Crit Care Med 2005;172:123–127.[Abstract/Free Full Text]
  2. Mallory KF, Churchyard GJ, Kleinschmidt I, De Cock KM, Corbett EL. The impact of HIV infection on recurrence of tuberculosis in South African gold miners. Int J Tuberc Lung Dis 2000;4:455–462.[Medline]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society