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American Journal of Respiratory and Critical Care Medicine Vol 170. pp. 1034, (2004)
© 2004 American Thoracic Society

Correspondence

Patient Outcome of Invasive Experiments

To the Editor:

Patient outcome of invasive experiments should be included in the reporting article. Two examples from the AJRCCM illustrate why.

Liu and coworkers (1) performed bronchoscopy, segmental allergen bronchoprovocation, and bronchial lavage on patients with allergic asthma. Ali and coworkers (2) repeatedly administered allergen-derived T cell peptides to volunteers with allergic asthma. Allergen challenge entails well known risks, as does bronchoscopy.

Neither report (1, 2) commented on clinical outcome, such as complications requiring treatment. Neither mentioned patient follow-up. Ethics boards granted approval to perform the studies; participants gave informed consent.

Patient outcomes may inform future decisions. Outcomes of study participants should be fed back to the Ethics board, and should be presented to the scientific community. If I were a patient, I would like to know.

Journals can ensure such safety reporting.

Christoph Pechlaner

Innsbruck University Hospital Innsbruck, Austria

FOOTNOTES

Conflict of Interest Statement: C.P. does not have a financial relationship with a commercial entity that has an interest in the subject of this letter.

Dr. A. Barry Kay was given the opportunity to respond to this letter but declined to do so.

REFERENCES

  1. Liu L, Jarjour NN, Busse WW, Kelly EA. Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma. Am J Respir Crit Care Med 2004;169:1118–1124.[Abstract/Free Full Text]
  2. Ali FR, Oldfield WL, Higashi N, Larche M, Kay AB. Late asthmatic reactions induced by inhalation of allergen-derived T cell peptides. Am J Respir Crit Care Med 2004;169:20–26.[Abstract/Free Full Text]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society