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Contributions of Dust Exposure and Cigarette Smoking to Emphysema Severity in Coal Miners in the United States

¹ National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio; ² National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, West Virginia; ³ Department of Pathology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

Correspondence and requests for reprints should be addressed to Eileen D. Kuempel, Ph.D., National Institute for Occupational Safety and Health, 4676 Columbia Parkway, M.S. C-15, Cincinnati, OH 45226-1998. E-mail: ekuempel{at}cdc.gov

Rationale: Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated.

Objectives: To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity.

Methods: The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models.

Measurements and Main Results: Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort.

Conclusions: Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study.

Key Words: occupational exposure • regression analysis • chronic obstructive lung disease • autopsy • severity of illness index

AT A GLANCE COMMENTARY Scientific Knowledge on the Subject Cumulative dust exposure is a significant predictor of emphysema severity in coal miners after accounting for cigarette smoking, age at death, and race. Coal mine dust exposure and cigarette smoking had similar additive effects on emphysema severity in these models. What This Study Adds to the Field Quantitative estimates of the contributions of smoking and dust exposure on emphysema severity in coal miners support the role of occupational dust exposure in chronic obstructive pulmonary disease.

 

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