Adam Giangreco1,
Karen R. Groot2 and
Sam M. Janes2
1 Keratinocyte Laboratory, Cancer Research UK, London, United Kingdom; and 2 Centre of Respiratory Research, University College London, London, United Kingdom
Correspondence and requests for reprints should be addressed to Sam M. Janes, M.D., Ph.D., Centre of Respiratory Research, Rayne Building, University College London, 5 University Street, London, WC1E 6JJ UK. E-mail: s.janes{at}ucl.ac.uk
ABSTRACT
Lung cancer is a significant disease with survival rates remainingpoor despite numerous therapeutic advances during the last 30years. Understanding lung cancer pathogenesis through murinemodeling may improve future human therapies, and new data indicatethat mutations within different endogenous stem cells situatedthroughout airways can drive cancer formation. Airway stem cellsmaintain prototumorigenic characteristics, including high proliferativecapacity, multipotent differentiation, and a long lifespan relativeto other cells. These cells localize to proximal airway submucosalglands/intercartilagenous rings, neuroepithelial bodies, andterminal bronchioles/bronchoalveolar duct junctions. Recentstudies suggest that endogenous stem cell signaling and differentiationpathways are maintained within distinct cancer types, and thatdestabilization of this signaling machinery may initiate region-specificlung cancers. A better understanding of this relationship amongstem cell regulation, cellular mutation, and lung cancer oncogenesisis critical for developing the next wave of lung cancer therapies.
J. R. Kratz, A. Yagui-Beltran, and D. M. Jablons Cancer Stem Cells in Lung Tumorigenesis
Ann. Thorac. Surg.,
June 1, 2010;
89(6):
S2090 - S2095.
[Abstract][Full Text][PDF]
A. Giangreco, E. N. Arwert, I. R. Rosewell, J. Snyder, F. M. Watt, and B. R. Stripp From the Cover: Stem cells are dispensable for lung homeostasis but restore airways after injury
PNAS,
June 9, 2009;
106(23):
9286 - 9291.
[Abstract][Full Text][PDF]
I. De Proost, I. Pintelon, W. J. Wilkinson, S. Goethals, I. Brouns, L. Van Nassauw, D. Riccardi, J.-P. Timmermans, P. J. Kemp, and D. Adriaensen Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging
FASEB J,
April 1, 2009;
23(4):
1153 - 1160.
[Abstract][Full Text][PDF]
R. J. van Klaveren, S. C. van't Westeinde, B.-J. de Hoop, and H. C. Hoogsteden Stem Cells and the Natural History of Lung Cancer: Implications for Lung Cancer Screening
Clin. Cancer Res.,
April 1, 2009;
15(7):
2215 - 2218.
[Abstract][Full Text][PDF]
F. Jiang, Q. Qiu, A. Khanna, N. W. Todd, J. Deepak, L. Xing, H. Wang, Z. Liu, Y. Su, S. A. Stass, et al. Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
Mol. Cancer Res.,
March 1, 2009;
7(3):
330 - 338.
[Abstract][Full Text][PDF]
J. S. Dovey, S. J. Zacharek, C. F. Kim, and J. A. Lees Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion
PNAS,
August 19, 2008;
105(33):
11857 - 11862.
[Abstract][Full Text][PDF]
D. J. Weiss, J. K. Kolls, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Proceedings of the ATS,
July 15, 2008;
5(5):
637 - 667.
[Full Text][PDF]
V. P. Krymskaya Smooth Muscle like Cells in Pulmonary Lymphangioleiomyomatosis
Proceedings of the ATS,
January 1, 2008;
5(1):
119 - 126.
[Abstract][Full Text][PDF]
S. M. Janes and F. McCaughan Where next for lung cancer gene expression profiling?
Eur. Respir. J.,
July 1, 2007;
30(1):
5 - 6.
[Full Text][PDF]
D. Angeloni Molecular analysis of deletions in human chromosome 3p21 and the role of resident cancer genes in disease
Briefings in Functional Genomics,
May 24, 2007;
(2007)
elm007v1.
[Abstract][Full Text][PDF]
