help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on June 15, 2006, doi:10.1164/rccm.200602-243OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200602-243OCv1
174/6/626    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aronson, D.
Right arrow Articles by Markiewicz, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aronson, D.
Right arrow Articles by Markiewicz, W.
American Journal of Respiratory and Critical Care Medicine Vol 174. pp. 626-632, (2006)
© 2006 American Thoracic Society
doi: 10.1164/rccm.200602-243OC

Original Article

Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects

Doron Aronson, Inon Roterman, Mordechay Yigla, Arthur Kerner, Ophir Avizohar, Ron Sella, Peter Bartha, Yishai Levy and Walter Markiewicz

Departments of Cardiology, Pulmonology, and Internal Medicine; and Center for Preventive Medicine, Rambam Medical Center and Rappaport Faculty of Medicine, Haifa, Israel

Correspondence and requests for reprints should be addressed to Doron Aronson, M.D., Department of Cardiology, Rambam Medical Center, POB 9602, Haifa 31096, Israel. E-mail: daronson{at}techunix.technion.ac.il

Rationale: Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function due to obstructive or restrictive lung disease.

Objective: We tested the hypothesis that a decline in lung function within the normal range may be associated with a systemic subclinical inflammation.

Methods: Pulmonary function tests, cardiorespiratory fitness, components of the metabolic syndrome, and high-sensitivity C-reactive protein (CRP) were determined in 1,131 subjects without known pulmonary disease.

Measurements and Main Results: Ninety-six of the study participants (8.5%) had FEV1 of less than 80% of predicted values. There was a strong inverse association between CRP levels and quartiles of FEV1. The median CRP levels in nonsmoking participants were 2.5, 1.8, 1.7, and 1.3 mg/L in the first, second, third, and forth FEV1 quartiles, respectively (p < 0.0001). A similar inverse association was present in smoking subjects (median CRP levels were 3.8, 2.3, 2.0, and 1.9 mg/L in the first, second, third, and fourth FEV1 quartiles, respectively; p < 0.0001). These associations remained highly significant after adjustment for age, sex, components of the metabolic syndrome, and fitness level (p = 0.0005).

Conclusions: An inverse linear relationship exists between CRP concentrations and measures of pulmonary function in subjects without pulmonary disease and in never-smokers. These results indicate that systemic inflammation may be linked to early perturbations of pulmonary function.

Key Words: C-reactive protein • forced vital capacity • obesity • physical fitness • systemic inflammation




This article has been cited by other articles:


Home page
 ThoraxHome page
J-Q He, M G Foreman, K Shumansky, X Zhang, L Akhabir, D D Sin, S F P Man, D L DeMeo, A A Litonjua, E K Silverman, et al.
Associations of IL6 polymorphisms with lung function decline and COPD
Thorax, August 1, 2009; 64(8): 698 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
R P Young, R Hopkins, and T E Eaton
Potential benefits of statins on morbidity and mortality in chronic obstructive pulmonary disease: a review of the evidence
Postgrad. Med. J., August 1, 2009; 85(1006): 414 - 421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. D. Flouris, G. S. Metsios, A. E. Carrillo, A. Z. Jamurtas, K. Gourgoulianis, T. Kiropoulos, M. N. Tzatzarakis, A. M. Tsatsakis, and Y. Koutedakis
Acute and Short-term Effects of Secondhand Smoke on Lung Function and Cytokine Production
Am. J. Respir. Crit. Care Med., June 1, 2009; 179(11): 1029 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. M.T.A. van Durme, K. M.C. Verhamme, A.-J. L.H.J. Aarnoudse, G. R. Van Pottelberge, A. Hofman, J. C.M. Witteman, G. F. Joos, G. G. Brusselle, and B. H.C. Stricker
C-Reactive Protein Levels, Haplotypes, and the Risk of Incident Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., March 1, 2009; 179(5): 375 - 382.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Rasmussen, D. Mikkelsen, R. J. Hancox, J. Lambrechtsen, M. Nybo, H. S. Hansen, and H. C. Siersted
High-sensitive C-reactive protein is associated with reduced lung function in young adults
Eur. Respir. J., February 1, 2009; 33(2): 382 - 388.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
W. MacNee, J. Maclay, and D. McAllister
Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, December 1, 2008; 5(8): 824 - 833.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Sunyer, R. Pistelli, E. Plana, M. Andreani, F. Baldari, M. Kolz, W. Koenig, J. Pekkanen, A. Peters, and F. Forastiere
Systemic inflammation, genetic susceptibility and lung function
Eur. Respir. J., July 1, 2008; 32(1): 92 - 97.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. D. Sin and S. F. P. Man
Biomarkers in COPD: Are We There Yet?
Chest, June 1, 2008; 133(6): 1296 - 1298.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Dahl
Biomarkers for Chronic Obstructive Pulmonary Disease: Surfactant Protein D and C-Reactive Protein
Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1177 - 1178.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. L. Stolzmann, D. R. Gagnon, R. Brown, C. G. Tun, and E. Garshick
Longitudinal Change in FEV1 and FVC in Chronic Spinal Cord Injury
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 781 - 786.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. E. Walter, J. B. Wilk, M. G. Larson, R. S. Vasan, J. F. Keaney Jr, I. Lipinska, G. T. O'Connor, and E. J. Benjamin
Systemic Inflammation and COPD: The Framingham Heart Study
Chest, January 1, 2008; 133(1): 19 - 25.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R. J Hancox, R. Poulton, J. M Greene, S. Filsell, C. R McLachlan, F. Rasmussen, D R. Taylor, M. J A Williams, A. Williamson, and M. R Sears
Systemic inflammation and lung function in young adults
Thorax, December 1, 2007; 62(12): 1064 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. Alexeeff, A. A. Litonjua, D. Sparrow, P. S. Vokonas, and J. Schwartz
Statin Use Reduces Decline in Lung Function: VA Normative Aging Study
Am. J. Respir. Crit. Care Med., October 15, 2007; 176(8): 742 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Agusti
Systemic Effects of Chronic Obstructive Pulmonary Disease: What We Know and What We Don't Know (but Should)
Proceedings of the ATS, October 1, 2007; 4(7): 522 - 525.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D. A Mahler
Is physical activity anti-inflammatory on the airways?
Thorax, May 1, 2007; 62(5): 376 - 376.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. C. Moore and S. P. Peters
Update in Asthma 2006
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 649 - 654.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Dahl, J. Vestbo, P. Lange, S. E. Bojesen, A. Tybjaerg-Hansen, and B. G. Nordestgaard
C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 250 - 255.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  CCM abstracts